Protein profile

KP13_00471

putative biofilm PGA synthesis protein pgaD

Genome: KpKP13

Gene: AHE46795.1 pgaD Structure source: AlphaFold + ColabFold UniProt A0A0H3GQE1
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Amino acids 150
Annotations 1
Features 11
PDB binders 0
Druggability 0.925

Overview

Basic information about this protein and its source genome.

Accession
KP13_00471
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46795.1 pgaD
Status
annotated
Amino acids
150
Structure source
AlphaFold + ColabFold
GO
GO:0043709 The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
62.01

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.925
Structure A0A0H3GQE1
Pocket Pocket 1
P2Rank
Structure A0A0H3GQE1
Pocket No pockets
ColabFold model
FPocket 0.914 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 22 / 4744 genomes with a hit
Normalized 0.005

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0043709 The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
1 20 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
23 45 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
21 41 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
61 81 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
7 133 Pfam PF13994 PgaD-like protein
7 133 InterPro IPR023829 Poly-beta-1,6-N-acetyl-D-glucosamine biosynthesis protein PgaD
82 150 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
7 135 NCBIfam TIGR03940 poly-beta-1,6-N-acetyl-D-glucosamine biosynthesis protein PgaD
7 135 InterPro IPR023829 Poly-beta-1,6-N-acetyl-D-glucosamine biosynthesis protein PgaD
60 82 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
42 60 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQE1
AlphaFold — — full sequence — Viewing
ColabFold KP13_00471
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.925
9 0.477
12 0.444