Protein profile

KP13_00470

putative protein-folding factor DsbA

Genome: KpKP13

Gene: dsbA AHE46796.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GHV8
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Amino acids 261
Annotations 0
Features 18
PDB binders 0
Druggability 0.303

Overview

Basic information about this protein and its source genome.

Accession
KP13_00470
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
dsbA AHE46796.1
Status
annotated
Amino acids
261
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
91.21

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.303
Structure A0A0H3GHV8
Pocket Pocket 5
P2Rank
Structure A0A0H3GHV8
Pocket No pockets
ColabFold model
FPocket 0.129 · Pocket 15
P2Rank 0.017 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 23 / 4744 genomes with a hit
Normalized 0.005

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
1 24 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
25 261 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
8 18 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 24 SignalP_EUK SignalP-noTM SignalP-noTM
1 7 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
94 257 CDD cd03023 DsbA_Com1_like
35 68 Pfam PF18312 Copper resistance protein ScsC N-terminal domain
35 68 InterPro IPR041205 Copper resistance protein ScsC, N-terminal
7 229 PANTHER PTHR35891 THIOL:DISULFIDE INTERCHANGE PROTEIN DSBA
19 24 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
79 257 SUPERFAMILY SSF52833 Thioredoxin-like
79 257 InterPro IPR036249 Thioredoxin-like superfamily
1 24 Phobius SIGNAL_PEPTIDE Signal peptide region
46 260 Gene3D G3DSA:3.40.30.10 Glutaredoxin
88 229 Pfam PF13462 Thioredoxin
88 229 InterPro IPR012336 Thioredoxin-like fold
64 261 ProSiteProfiles PS51352 Thioredoxin domain profile.
64 261 InterPro IPR013766 Thioredoxin domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GHV8
AlphaFold — — full sequence — Viewing
ColabFold KP13_00470
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.303