Protein profile

KP13_00469

TerC family integral membrane protein

Genome: KpKP13

Gene: terC AHE46797.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GL68
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Amino acids 252
Annotations 1
Features 28
PDB binders 0
Druggability 0.518

Overview

Basic information about this protein and its source genome.

Accession
KP13_00469
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
terC AHE46797.1
Status
annotated
Amino acids
252
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
40.278
DEG E-value
9.250000000000001e-35
Localization
CytoplasmicMembrane
ColabFold pLDDT
84.43

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.518
Structure A0A0H3GL68
Pocket Pocket 1
P2Rank 0.071
Structure A0A0H3GL68
Pocket Pocket 1
ColabFold model
FPocket 0.709 · Pocket 5
P2Rank 0.192 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 39 / 4744 genomes with a hit
Normalized 0.008

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

28 records
Show feature table
Start End DB Term Name
162 184 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
13 30 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
243 252 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
185 204 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
61 71 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
99 116 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
205 223 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
12 30 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
36 60 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
31 35 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
72 93 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
156 160 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
39 211 NCBIfam TIGR03717 YjbE family putative metal transport protein
39 211 InterPro IPR022301 Integral membrane protein YjbE
117 135 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
40 210 Pfam PF03741 Integral membrane protein TerC family
40 210 InterPro IPR005496 Integral membrane protein TerC
25 126 PANTHER PTHR30238 MEMBRANE BOUND PREDICTED REDOX MODULATOR
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
225 242 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
78 100 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
224 242 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
35 57 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
179 184 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
94 98 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
161 178 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
191 210 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
136 155 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GL68
AlphaFold — — full sequence — Viewing
ColabFold KP13_00469
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.404
3 0.0
11 0.0
15 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.82 0.071
2 2.31 0.048
3 2.04 0.037
4 1.35 0.013