Protein profile

KP13_00455

Protein phnH

Genome: KpKP13

Gene: phnH AHE46811.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQC5
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Amino acids 194
Annotations 2
Features 10
PDB binders 0
Druggability 0.668

Overview

Basic information about this protein and its source genome.

Accession
KP13_00455
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
phnH AHE46811.1
Status
annotated
Amino acids
194
Structure source
AlphaFold + ColabFold
GO
GO:0019634 The chemical reactions and pathways involving phosphonates, any organic compounds containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Metabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included. GO:0016829 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
96.93

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.668
Structure A0A0H3GQC5
Pocket Pocket 1
P2Rank 0.06
Structure A0A0H3GQC5
Pocket Pocket 1
ColabFold model
FPocket 0.085 · Pocket 4
P2Rank 0.035 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 73 / 4744 genomes with a hit
Normalized 0.015

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0019634 The chemical reactions and pathways involving phosphonates, any organic compounds containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Metabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included.
  • GO:0016829 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
7 190 NCBIfam TIGR03292 phosphonate C-P lyase system protein PhnH
7 190 InterPro IPR008772 Bacterial phosphonate metabolism, PhnH
1 194 PIRSF PIRSF020680 PhnH
1 194 InterPro IPR008772 Bacterial phosphonate metabolism, PhnH
1 194 Gene3D G3DSA:3.40.50.11310 Bacterial phosphonate metabolism protein PhnH
1 194 InterPro IPR038058 PhnH-like superfamily
6 192 Pfam PF05845 Bacterial phosphonate metabolism protein (PhnH)
6 192 InterPro IPR008772 Bacterial phosphonate metabolism, PhnH
13 193 SUPERFAMILY SSF159709 PhnH-like
13 193 InterPro IPR038058 PhnH-like superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQC5
AlphaFold — — full sequence — Viewing
ColabFold KP13_00455
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.668

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.07 0.046