Protein profile

KP13_00453

Protein phnJ

Genome: KpKP13

Gene: phnJ AHE46813.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GM34
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Amino acids 282
Annotations 3
Features 7
PDB binders 0
Druggability 0.282

Overview

Basic information about this protein and its source genome.

Accession
KP13_00453
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
phnJ AHE46813.1
Status
annotated
Amino acids
282
Structure source
AlphaFold + ColabFold
GO
GO:0016829 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0019700 The chemical reactions and pathways resulting in the breakdown of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Catabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
95.65

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.282
Structure A0A0H3GM34
Pocket Pocket 3
P2Rank 0.12
Structure A0A0H3GM34
Pocket Pocket 1
ColabFold model
FPocket 0.417 · Pocket 3
P2Rank 0.124 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 199 / 4744 genomes with a hit
Normalized 0.042

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016829 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
  • GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
  • GO:0019700 The chemical reactions and pathways resulting in the breakdown of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Catabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included.

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
7 277 Pfam PF06007 Phosphonate metabolism protein PhnJ
7 277 InterPro IPR010306 Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase
5 280 SFLD SFLDS00033 Radical SAM Phosphonate Metabolism
5 280 SFLD SFLDG01115 Phosphonate metabolism (PhnJ)
1 282 PIRSF PIRSF011468 PhnJ
1 282 InterPro IPR010306 Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase
7 277 SFLD SFLDF00379 Phosphonate metabolism (PhnJ)

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GM34
AlphaFold — — full sequence — Viewing
ColabFold KP13_00453
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.282
5 0.246
6 0.24
25 0.205

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.28 0.114
2 2.15 0.05
3 1.09 0.007