Protein profile

KP13_00449

Ribose 1,5-bisphosphate phosphokinase PhnN

Genome: KpKP13

Gene: phnN AHE46817.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GHS3
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Amino acids 187
Annotations 5
Features 13
PDB binders 0
Druggability 0.767

Overview

Basic information about this protein and its source genome.

Accession
KP13_00449
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
phnN AHE46817.1
Status
annotated
Amino acids
187
Structure source
AlphaFold + ColabFold
EC
2.7.4.23
GO
GO:0033863 Catalysis of the reaction: D-ribose 1,5-diphosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + ADP + H+. GO:0006015 The chemical reactions and pathways resulting in the formation of 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate. GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0019634 The chemical reactions and pathways involving phosphonates, any organic compounds containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Metabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
92.24

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.767
Structure A0A0H3GHS3
Pocket Pocket 1
P2Rank 0.397
Structure A0A0H3GHS3
Pocket Pocket 1
ColabFold model
FPocket 0.543 · Pocket 4
P2Rank 0.774 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 69 / 4744 genomes with a hit
Normalized 0.015

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0033863 Catalysis of the reaction: D-ribose 1,5-diphosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + ADP + H+.
  • GO:0006015 The chemical reactions and pathways resulting in the formation of 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate.
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0019634 The chemical reactions and pathways involving phosphonates, any organic compounds containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Metabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
1 180 FunFam G3DSA:3.40.50.300:FF:000979 Ribose 1,5-bisphosphate phosphokinase PhnN
2 149 PANTHER PTHR23117 GUANYLATE KINASE-RELATED
1 183 Gene3D G3DSA:3.40.50.300 -
1 183 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
3 177 NCBIfam TIGR02322 phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN
3 177 InterPro IPR012699 Ribose 1,5-bisphosphate phosphokinase PhnN
3 179 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
3 179 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
2 179 SMART SM00072 gk_7
2 179 InterPro IPR008145 Guanylate kinase/L-type calcium channel beta subunit
6 138 Pfam PF13238 AAA domain
2 176 Hamap MF_00836 Ribose 1,5-bisphosphate phosphokinase PhnN [phnN].
2 176 InterPro IPR012699 Ribose 1,5-bisphosphate phosphokinase PhnN

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GHS3
AlphaFold — — full sequence — Viewing
ColabFold KP13_00449
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.767

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.77 0.211
2 2.5 0.069