Protein profile

KP13_00436

TPR-like domain-containing protein

Genome: KpKP13

Gene: AHE46829.1 Structure source: Experimental + ColabFold UniProt A6TH02
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Amino acids 228
Annotations 1
Features 29
PDB binders 0
Druggability 0.343

Overview

Basic information about this protein and its source genome.

Accession
KP13_00436
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46829.1
Status
annotated
Amino acids
228
Structure source
Experimental + ColabFold
GO
GO:0005515 Binding to a protein.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
93.83

Selected Druggability evidence

PDB experimental structure

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.343
Structure 3RJV
Pocket Pocket 1
P2Rank 0.046
Structure 3RJV
Pocket Pocket 1
ColabFold model
FPocket 0.299 · Pocket 1
P2Rank 0.172 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 49 / 4744 genomes with a hit
Normalized 0.01

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1

Sequence Features

Domain/signature hits from InterPro and related databases.

29 records
Show feature table
Start End DB Term Name
24 100 SUPERFAMILY SSF81901 HCP-like
1 18 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
4 12 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
83 100 Pfam PF08238 Sel1 repeat
83 100 InterPro IPR006597 Sel1-like repeat
142 169 Pfam PF08238 Sel1 repeat
142 169 InterPro IPR006597 Sel1-like repeat
36 65 Pfam PF08238 Sel1 repeat
36 65 InterPro IPR006597 Sel1-like repeat
179 208 Pfam PF08238 Sel1 repeat
179 208 InterPro IPR006597 Sel1-like repeat
25 140 PANTHER PTHR11102 SEL-1-LIKE PROTEIN
164 228 Gene3D G3DSA:1.25.40.740 -
66 100 SMART SM00671 sel1
66 100 InterPro IPR006597 Sel1-like repeat
141 176 SMART SM00671 sel1
141 176 InterPro IPR006597 Sel1-like repeat
34 65 SMART SM00671 sel1
34 65 InterPro IPR006597 Sel1-like repeat
178 215 SMART SM00671 sel1
178 215 InterPro IPR006597 Sel1-like repeat
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 18 Phobius SIGNAL_PEPTIDE Signal peptide region
1 18 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
19 228 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
18 163 Gene3D G3DSA:1.25.40.10 Tetratricopeptide repeat domain
18 163 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
13 18 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
82 213 SUPERFAMILY SSF81901 HCP-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 3RJV
X-ray 20.00 Å - —
PDBe RCSB PDBj File
Viewing
ColabFold KP13_00436
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.343

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.06 0.046
2 1.38 0.017