Protein profile

KP13_00430

putative adhesin

Genome: KpKP13

Gene: AHE46835.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GHP3
Export view
Amino acids 367
Annotations 3
Features 17
PDB binders 0
Druggability 0.035

Overview

Basic information about this protein and its source genome.

Accession
KP13_00430
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46835.1
Status
annotated
Amino acids
367
Structure source
AlphaFold + ColabFold
GO
GO:0007155 The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0009289 A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. GO:0043709 The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Extracellular
ColabFold pLDDT
91.8

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.035
Structure A0A0H3GHP3
Pocket Pocket 13
P2Rank 0.467
Structure A0A0H3GHP3
Pocket Pocket 1
ColabFold model
FPocket 0.061 · Pocket 2
P2Rank 0.476 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 8 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0007155 The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
  • GO:0009289 A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter.
  • GO:0043709 The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
3 367 PANTHER PTHR33420 FIMBRIAL SUBUNIT ELFA-RELATED
22 367 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 5 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
216 366 Pfam PF00419 Fimbrial protein
216 366 InterPro IPR000259 Fimbrial-type adhesion domain
1 21 SignalP_EUK SignalP-noTM SignalP-noTM
22 211 Gene3D G3DSA:2.60.40.3310 -
6 17 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 21 Phobius SIGNAL_PEPTIDE Signal peptide region
7 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 21 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
212 367 Gene3D G3DSA:2.60.40.1090 -
212 367 InterPro IPR036937 Fimbrial-type adhesion domain superfamily
18 21 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 23 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
210 367 SUPERFAMILY SSF49401 Bacterial adhesins
210 367 InterPro IPR008966 Adhesion domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GHP3
AlphaFold — — full sequence — Viewing
ColabFold KP13_00430
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 8.19 0.436
2 3.34 0.118
3 1.17 0.01