Protein profile

KP13_00428

Fimbrial biogenesis outer membrane usher protein

Genome: KpKP13

Gene: AHE46837.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GL33
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Amino acids 741
Annotations 5
Features 20
PDB binders 0
Druggability 0.779

Overview

Basic information about this protein and its source genome.

Accession
KP13_00428
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46837.1
Status
annotated
Amino acids
741
Structure source
AlphaFold + ColabFold
GO
GO:0005515 Binding to a protein. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015473 A porin that acts in the assembly of fimbria together with fimbrial chaperone. GO:0009297 The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles. GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
OuterMembrane
ColabFold pLDDT
87.25

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.779
Structure A0A0H3GL33
Pocket Pocket 57
P2Rank 0.9
Structure A0A0H3GL33
Pocket Pocket 1
ColabFold model
FPocket 0.615 · Pocket 5
P2Rank 0.573 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 11 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005515 Binding to a protein.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0015473 A porin that acts in the assembly of fimbria together with fimbrial chaperone.
  • GO:0009297 The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles.
  • GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
4 740 PANTHER PTHR30451 OUTER MEMBRANE USHER PROTEIN
4 740 InterPro IPR000015 Outer membrane usher protein
159 248 FunFam G3DSA:2.60.40.3110:FF:000001 Putative fimbrial outer membrane usher
2 73 Pfam PF13954 PapC N-terminal domain
2 73 InterPro IPR025885 PapC, N-terminal domain
658 724 Pfam PF13953 PapC C-terminal domain
658 724 InterPro IPR025949 PapC-like, C-terminal domain
655 741 Gene3D G3DSA:2.60.40.2070 -
655 741 InterPro IPR043142 PapC-like, C-terminal domain superfamily
9 65 SUPERFAMILY SSF141729 FimD N-terminal domain-like
9 65 InterPro IPR037224 PapC, N-terminal domain superfamily
201 211 ProSitePatterns PS01151 Fimbrial biogenesis outer membrane usher protein signature.
201 211 InterPro IPR018030 Fimbrial membrane usher, conserved site
1 62 Gene3D G3DSA:3.10.20.410 -
1 62 InterPro IPR037224 PapC, N-terminal domain superfamily
159 248 Gene3D G3DSA:2.60.40.3110 -
565 654 Gene3D G3DSA:2.60.40.2610 Outer membrane usher protein FimD, plug domain
565 654 InterPro IPR042186 Outer membrane usher protein FimD, plug domain
91 648 Pfam PF00577 Outer membrane usher protein
91 648 InterPro IPR000015 Outer membrane usher protein

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GL33
AlphaFold — — full sequence — Viewing
ColabFold KP13_00428
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
57 0.779
1 0.221

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 15.02 0.742
2 8.32 0.443
3 5.15 0.237
4 4.71 0.207
5 4.54 0.194