Protein profile

KP13_00425

LrgB family protein

Genome: KpKP13

Gene: AHE46841.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GM07
Export view
Amino acids 229
Annotations 0
Features 23
PDB binders 0
Druggability 0.966

Overview

Basic information about this protein and its source genome.

Accession
KP13_00425
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46841.1
Status
annotated
Amino acids
229
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
94.64

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.966
Structure A0A0H3GM07
Pocket Pocket 16
P2Rank 0.278
Structure A0A0H3GM07
Pocket Pocket 1
ColabFold model
FPocket 0.731 · Pocket 1
P2Rank 0.353 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 88 / 4744 genomes with a hit
Normalized 0.019

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

23 records
Show feature table
Start End DB Term Name
81 91 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
204 228 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
14 224 Pfam PF04172 LrgB-like family
14 224 InterPro IPR007300 CidB/LrgB family
113 147 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
92 112 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
229 229 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
63 80 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
149 171 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
170 203 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
34 53 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
4 228 PANTHER PTHR30249 PUTATIVE SEROTONIN TRANSPORTER
4 228 InterPro IPR007300 CidB/LrgB family
90 112 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
33 57 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 5 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
204 226 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
22 32 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
58 62 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
63 85 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
148 169 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
4 21 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
6 21 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GM07
AlphaFold — — full sequence — Viewing
ColabFold KP13_00425
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
16 0.966
9 0.759
3 0.691
10 0.462

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.74 0.143
2 2.38 0.063
3 2.35 0.061
4 2.0 0.043
5 1.99 0.042