Protein profile

KP13_00411

Alpha-glucoside transport system permease protein aglF

Genome: KpKP13

Gene: AHE46851.1 aglF Structure source: AlphaFold + ColabFold UniProt A0A0H3GL23
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Amino acids 277
Annotations 3
Features 32
PDB binders 0
Druggability 0.872

Overview

Basic information about this protein and its source genome.

Accession
KP13_00411
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46851.1 aglF
Status
annotated
Amino acids
277
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
90.92

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.872
Structure A0A0H3GL23
Pocket Pocket 1
P2Rank 0.089
Structure A0A0H3GL23
Pocket Pocket 1
ColabFold model
FPocket 0.957 · Pocket 1
P2Rank 0.055 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 11 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

32 records
Show feature table
Start End DB Term Name
85 95 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
197 224 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
24 33 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
76 263 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
76 263 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
118 155 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
202 224 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 7 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
61 83 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
8 23 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
148 170 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
7 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
244 266 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
81 258 CDD cd06261 TM_PBP2
81 258 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
96 117 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
57 265 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
57 265 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
4 271 Gene3D G3DSA:1.10.3720.10 -
4 271 InterPro IPR035906 MetI-like superfamily
178 196 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
267 277 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
34 56 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 33 Phobius SIGNAL_PEPTIDE Signal peptide region
5 270 PANTHER PTHR42929 INNER MEMBRANE ABC TRANSPORTER PERMEASE PROTEIN YDCU-RELATED-RELATED
244 266 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
156 177 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
5 271 SUPERFAMILY SSF161098 MetI-like
5 271 InterPro IPR035906 MetI-like superfamily
57 84 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
225 243 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
96 118 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GL23
AlphaFold — — full sequence — Viewing
ColabFold KP13_00411
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.872
6 0.801
11 0.26
8 0.221

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.99 0.042
2 1.66 0.028