Protein profile

KP13_00405

Anti-adapter protein iraM

Genome: KpKP13

Gene: iraM AHE46857.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GGX7
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Amino acids 117
Annotations 2
Features 11
PDB binders 0
Druggability 0.169

Overview

Basic information about this protein and its source genome.

Accession
KP13_00405
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
iraM AHE46857.1
Status
annotated
Amino acids
117
Structure source
AlphaFold + ColabFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0009267 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
83.9

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.169
Structure A0A0H3GGX7
Pocket Pocket 10
P2Rank 0.021
Structure A0A0H3GGX7
Pocket Pocket 1
ColabFold model
FPocket 0.409 · Pocket 1
P2Rank 0.074 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 9 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0009267 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
1 2 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
20 117 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 82 Gene3D G3DSA:2.40.50.650 -
1 82 InterPro IPR038679 Signal transduction protein PmrD superfamily
1 19 Phobius SIGNAL_PEPTIDE Signal peptide region
12 19 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
3 11 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 111 Hamap MF_01199 Anti-adapter protein IraM [iraM].
1 111 InterPro IPR014448 Anti-adapter protein IraM
1 76 Pfam PF11183 Polymyxin resistance protein PmrD
1 76 InterPro IPR044854 Signal transduction protein PmrD

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GGX7
AlphaFold — — full sequence — Viewing
ColabFold KP13_00405
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer