Protein profile

KP13_00400

Transcriptional regulator, AraC family protein

Genome: KpKP13

Gene: AHE46862.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GGX2
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Amino acids 116
Annotations 3
Features 17
PDB binders 0
Druggability 0.745

Overview

Basic information about this protein and its source genome.

Accession
KP13_00400
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46862.1
Status
annotated
Amino acids
116
Structure source
AlphaFold + ColabFold
GO
GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
94.91

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.745
Structure A0A0H3GGX2
Pocket Pocket 1
P2Rank 0.038
Structure A0A0H3GGX2
Pocket Pocket 1
ColabFold model
FPocket 0.376 · Pocket 3
P2Rank 0.038 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 7 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
58 116 Gene3D G3DSA:1.10.10.60 -
7 57 Gene3D G3DSA:1.10.10.60 -
12 111 ProSiteProfiles PS01124 Bacterial regulatory proteins, araC family DNA-binding domain profile.
12 111 InterPro IPR018060 DNA binding HTH domain, AraC-type
32 109 Pfam PF12833 Helix-turn-helix domain
32 109 InterPro IPR018060 DNA binding HTH domain, AraC-type
10 60 SUPERFAMILY SSF46689 Homeodomain-like
10 60 InterPro IPR009057 Homeobox-like domain superfamily
6 111 PANTHER PTHR47504 RIGHT ORIGIN-BINDING PROTEIN
25 109 SMART SM00342 aracneu4
25 109 InterPro IPR018060 DNA binding HTH domain, AraC-type
62 112 SUPERFAMILY SSF46689 Homeodomain-like
62 112 InterPro IPR009057 Homeobox-like domain superfamily
93 109 PRINTS PR00032 AraC bacterial regulatory protein HTH signature
93 109 InterPro IPR020449 Transcription regulator HTH, AraC- type
78 93 PRINTS PR00032 AraC bacterial regulatory protein HTH signature
78 93 InterPro IPR020449 Transcription regulator HTH, AraC- type

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GGX2
AlphaFold — — full sequence — Viewing
ColabFold KP13_00400
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.745
2 0.3

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.63 0.026