Protein profile

KP13_31593

Zinc uptake regulation protein

Genome: KpKP13

Gene: AHE46878.1 zur Structure source: AlphaFold + ColabFold UniProt A0A0H3GHI3
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Amino acids 171
Annotations 7
Features 14
PDB binders 0
Druggability 0.381

Overview

Basic information about this protein and its source genome.

Accession
KP13_31593
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46878.1 zur
Status
annotated
Amino acids
171
Structure source
AlphaFold + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0008270 Binding to a zinc ion (Zn). GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
90.76

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.381
Structure A0A0H3GHI3
Pocket Pocket 13
P2Rank 0.196
Structure A0A0H3GHI3
Pocket Pocket 1
ColabFold model
FPocket 0.395 · Pocket 12
P2Rank 0.256 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 117 / 4744 genomes with a hit
Normalized 0.025

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

7 GO

Gene Ontology (GO)

7
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
  • GO:0008270 Binding to a zinc ion (Zn).
  • GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:1900376 Any process that modulates the frequency, rate or extent of secondary metabolite biosynthetic process.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
90 152 Gene3D G3DSA:3.30.1490.190 -
90 152 InterPro IPR043135 Ferric-uptake regulator, C-terminal domain
20 138 Pfam PF01475 Ferric uptake regulator family
20 138 InterPro IPR002481 Ferric-uptake regulator
6 150 PANTHER PTHR33202 ZINC UPTAKE REGULATION PROTEIN
6 150 InterPro IPR002481 Ferric-uptake regulator
2 89 FunFam G3DSA:1.10.10.10:FF:000137 Zinc uptake transcriptional repressor
26 143 CDD cd07153 Fur_like
26 143 InterPro IPR002481 Ferric-uptake regulator
90 152 FunFam G3DSA:3.30.1490.190:FF:000002 Zinc uptake transcriptional repressor
1 89 Gene3D G3DSA:1.10.10.10 -
1 89 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
13 144 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
13 144 InterPro IPR036390 Winged helix DNA-binding domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GHI3
AlphaFold — — full sequence — Viewing
ColabFold KP13_31593
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
13 0.381

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.88 0.091