Protein profile

KP13_00378

Glycerol-3-phosphate acyltransferase

Genome: KpKP13

Gene: plsB AHE46883.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GLW5
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Amino acids 807
Annotations 6
Features 19
PDB binders 0
Druggability 0.794

Overview

Basic information about this protein and its source genome.

Accession
KP13_00378
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
plsB AHE46883.1
Status
annotated
Amino acids
807
Structure source
AlphaFold + ColabFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0044255 OBSOLETE. The chemical reactions and pathways involving lipids, as carried out by individual cells. GO:0016746 Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0008374 Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule. GO:0004366 Catalysis of the reaction: an acyl-CoA + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + CoA. GO:0008654 The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
37.64
Human E-value
4.45e-29
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
91.315
DEG E-value
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
90.31

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.794
Structure A0A0H3GLW5
Pocket Pocket 63
P2Rank 0.941
Structure A0A0H3GLW5
Pocket Pocket 1
ColabFold model
FPocket 0.26 · Pocket 14
P2Rank 0.887 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 142 / 4744 genomes with a hit
Normalized 0.03

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0044255 OBSOLETE. The chemical reactions and pathways involving lipids, as carried out by individual cells.
  • GO:0016746 Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).
  • GO:0008374 Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule.
  • GO:0004366 Catalysis of the reaction: an acyl-CoA + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + CoA.
  • GO:0008654 The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
300 427 SMART SM00563 plsc_2
300 427 InterPro IPR002123 Phospholipid/glycerol acyltransferase
11 799 NCBIfam TIGR03703 glycerol-3-phosphate 1-O-acyltransferase PlsB
11 799 InterPro IPR028354 Glycerol-3-phosphate acyltransferase, PlsB
246 482 SUPERFAMILY SSF69593 Glycerol-3-phosphate (1)-acyltransferase
2 807 PIRSF PIRSF500064 GPAT
2 807 InterPro IPR028354 Glycerol-3-phosphate acyltransferase, PlsB
142 784 PANTHER PTHR12563 GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE
142 784 InterPro IPR022284 Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase
282 424 Pfam PF01553 Acyltransferase
282 424 InterPro IPR002123 Phospholipid/glycerol acyltransferase
435 683 Pfam PF19277 Glycerol-3-phosphate acyltransferase C-terminal region
435 683 InterPro IPR045520 GPAT/DHAPAT, C-terminal domain
279 480 CDD cd07993 LPLAT_DHAPAT-like
279 480 InterPro IPR041728 GPAT/DHAPAT, acyltransferase domain
13 807 Hamap MF_00393 Glycerol-3-phosphate acyltransferase [plsB].
13 807 InterPro IPR028354 Glycerol-3-phosphate acyltransferase, PlsB
19 807 PIRSF PIRSF000437 GPAT_DHAPAT
19 807 InterPro IPR022284 Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GLW5
AlphaFold — — full sequence — Viewing
ColabFold KP13_00378
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
63 0.794
13 0.421
23 0.323

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 22.0 0.876
2 11.9 0.63
3 3.16 0.107
4 3.09 0.103
5 2.82 0.088