Protein profile

KP13_00375

Maltose operon periplasmic protein

Genome: KpKP13

Gene: malM AHE46886.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQ52
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Amino acids 307
Annotations 2
Features 11
PDB binders 0
Druggability 0.431

Overview

Basic information about this protein and its source genome.

Accession
KP13_00375
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
malM AHE46886.1
Status
annotated
Amino acids
307
Structure source
AlphaFold + ColabFold
GO
GO:0008643 The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Periplasmic
ColabFold pLDDT
81.63

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.431
Structure A0A0H3GQ52
Pocket Pocket 2
P2Rank 0.065
Structure A0A0H3GQ52
Pocket Pocket 1
ColabFold model
FPocket 0.463 · Pocket 3
P2Rank 0.023 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 87 / 4744 genomes with a hit
Normalized 0.018

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0008643 The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y.
  • GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
1 6 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
19 26 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 26 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 26 Phobius SIGNAL_PEPTIDE Signal peptide region
7 18 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
7 26 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
27 307 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 19 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
1 26 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
77 209 Pfam PF07148 Maltose operon periplasmic protein precursor (MalM)
77 209 InterPro IPR010794 Maltose operon periplasmic

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQ52
AlphaFold — — full sequence — Viewing
ColabFold KP13_00375
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.431

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.69 0.029