Protein profile

KP13_00374

Maltoporin 2

Genome: KpKP13

Gene: AHE46887.1 lamB2 Structure source: AlphaFold + ColabFold UniProt A0A0H3GHG7
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Amino acids 429
Annotations 10
Features 17
PDB binders 0
Druggability 0.718

Overview

Basic information about this protein and its source genome.

Accession
KP13_00374
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46887.1 lamB2
Status
annotated
Amino acids
429
Structure source
AlphaFold + ColabFold
GO
GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0042956 The directed movement of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, across a membrane. GO:0034219 The process in which a carbohydrate is transported across a membrane. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015481 Enables the transfer of maltose from one side of a membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch. This transporter is a porin so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. GO:0042958 Enables the transfer of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
OuterMembrane
ColabFold pLDDT
94.84

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.718
Structure A0A0H3GHG7
Pocket Pocket 10
P2Rank 0.663
Structure A0A0H3GHG7
Pocket Pocket 1
ColabFold model
FPocket 0.725 · Pocket 11
P2Rank 0.688 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 90 / 4744 genomes with a hit
Normalized 0.019

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

10 GO

Gene Ontology (GO)

10
  • GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
  • GO:0042956 The directed movement of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, across a membrane.
  • GO:0034219 The process in which a carbohydrate is transported across a membrane.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0015481 Enables the transfer of maltose from one side of a membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch. This transporter is a porin so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
  • GO:0042958 Enables the transfer of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, from one side of a membrane to the other.
  • GO:0015768 The directed movement of maltose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the catabolism of glycogen and starch.
  • GO:0015288 Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
  • GO:0046930 A protein complex providing a discrete opening in a membrane that allows the passage of gases and/or liquids.
  • GO:0006811 The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
19 25 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
8 18 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 25 Phobius SIGNAL_PEPTIDE Signal peptide region
1 7 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
4 429 Hamap MF_01301 Maltoporin [lamB].
4 429 InterPro IPR023738 Maltoporin
1 429 PANTHER PTHR38762 CRYPTIC OUTER MEMBRANE PORIN BGLH-RELATED
1 25 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
28 429 Pfam PF02264 LamB porin
28 429 InterPro IPR003192 Porin, LamB-type
26 429 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
26 429 CDD cd01346 Maltoporin-like
26 429 InterPro IPR003192 Porin, LamB-type
1 25 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
26 429 Gene3D G3DSA:2.40.170.10 Porin, LamB type
26 429 InterPro IPR036998 Porin, LamB-type superfamily
26 429 SUPERFAMILY SSF56935 Porins

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GHG7
AlphaFold — — full sequence — Viewing
ColabFold KP13_00374
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
10 0.718

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 8.88 0.475
2 5.19 0.24
3 2.18 0.052
4 1.89 0.038
5 1.55 0.023