Protein profile

KP13_00371

Maltose transport system permease protein malF

Genome: KpKP13

Gene: AHE46890.1 malF Structure source: AlphaFold + ColabFold UniProt A0A0H3GGU7

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Amino acids 514

Annotations 5

Features 47

PDB binders 0

Druggability 0.51

Overview

Basic information about this protein and its source genome.

Accession: KP13_00371
Assembly: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene: AHE46890.1 malF
Status: annotated
Amino acids: 514
Structure source: AlphaFold + ColabFold

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:1990060 Protein complex facilitating ATP-dependent maltose transport through inner cell membrane (periplasm to cytoplasm) in Gram-negative bacteria. In E. coli the system is composed of a periplasmic maltose-binding protein (MBP), two integral membrane proteins, MalF and MalG, and two copies of the cytoplasmic ATP-binding cassette MalK. GO:0015423 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + maltose(out) = ADP + phosphate + maltose(in). GO:0042956 The directed movement of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, across a membrane.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Human identity (%): 0.0
Gut microbiome off-target: hit
Essential (DEG): N
DEG identity (%): 0.0
Localization: CytoplasmicMembrane
ColabFold pLDDT: 90.37

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.51

Structure A0A0H3GGU7

Pocket Pocket 25

P2Rank 0.734

Structure A0A0H3GGU7

Pocket Pocket 1

ColabFold model

FPocket 0.4 · Pocket 2

P2Rank 0.591 · Pocket 1

Core conservation Conserved core gene

Roary core

CoreCruncher core

Gut microbiome 106 / 4744 genomes with a hit

Normalized 0.022

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
GO:1990060 Protein complex facilitating ATP-dependent maltose transport through inner cell membrane (periplasm to cytoplasm) in Gram-negative bacteria. In E. coli the system is composed of a periplasmic maltose-binding protein (MBP), two integral membrane proteins, MalF and MalG, and two copies of the cytoplasmic ATP-binding cassette MalK.
GO:0015423 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + maltose(out) = ADP + phosphate + maltose(in).
GO:0042956 The directed movement of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, across a membrane.

Sequence Features

Domain/signature hits from InterPro and related databases.

47 records

Show feature table

Start	End	DB	Term	Name
484	506	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
319	341	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
15	34	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
92	276	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
13	35	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
15	260	SUPERFAMILY	SSF160964	MalF N-terminal region-like
1	14	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
277	303	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
341	370	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
281	505	ProSiteProfiles	PS50928	ABC transporter integral membrane type-1 domain profile.
281	505	InterPro	IPR000515	ABC transporter type 1, transmembrane domain MetI-like
100	260	Pfam	PF14785	Maltose transport system permease protein MalF P2 domain
100	260	InterPro	IPR029345	Maltose transport system permease protein MalF, P2 domain
315	340	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
304	314	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
297	501	Pfam	PF00528	Binding-protein-dependent transport system inner membrane component
297	501	InterPro	IPR000515	ABC transporter type 1, transmembrane domain MetI-like
413	435	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
371	392	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
284	306	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
4	513	PANTHER	PTHR47314	MALTOSE/MALTODEXTRIN TRANSPORT SYSTEM PERMEASE PROTEIN MALF
370	392	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
118	205	FunFam	G3DSA:2.40.430.10:FF:000001	Maltose ABC transporter permease MalF
413	436	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
270	514	Gene3D	G3DSA:1.10.3720.10	-
270	514	InterPro	IPR035906	MetI-like superfamily
393	412	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
67	91	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
118	205	Gene3D	G3DSA:2.40.430.10	-
118	205	InterPro	IPR047103	Maltose transport system permease protein MalF, P2 domain superfamily
299	498	CDD	cd06261	TM_PBP2
299	498	InterPro	IPR000515	ABC transporter type 1, transmembrane domain MetI-like
59	66	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
70	92	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
270	514	FunFam	G3DSA:1.10.3720.10:FF:000030	Maltose ABC transporter permease MalF
1	95	Gene3D	G3DSA:1.20.58.370	-
1	95	InterPro	IPR035277	MalF, N-terminal
98	268	Gene3D	G3DSA:3.10.650.10	-
261	503	SUPERFAMILY	SSF161098	MetI-like
261	503	InterPro	IPR035906	MetI-like superfamily
484	506	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
40	58	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
437	483	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1	95	FunFam	G3DSA:1.20.58.370:FF:000001	Maltose ABC transporter permease MalF
507	514	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
35	39	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
40	57	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_A0A0H3GGU7	AlphaFold	—	—	full sequence	—	Viewing
ColabFold KP13_00371	ColabFold	—	—	full sequence	—	Loaded

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
25				0.51
15				0.185
6				0.0
13				0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Score	Probability
1	17.73	0.734
2	10.41	0.482
3	7.09	0.308
4	1.82	0.029
5	1.75	0.026

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.4

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Score	Probability
1	9.46	0.509
2	8.1	0.431
3	5.56	0.266
4	2.25	0.056
5	1.64	0.027