Protein profile

KP13_00368

Serine dehydratase-like, alpha subunit domain-containing protein

Genome: KpKP13

Gene: AHE46893.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GLV6
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Amino acids 425
Annotations 0
Features 11
PDB binders 0
Druggability 0.505

Overview

Basic information about this protein and its source genome.

Accession
KP13_00368
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46893.1
Status
annotated
Amino acids
425
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
93.85

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.505
Structure A0A0H3GLV6
Pocket Pocket 2
P2Rank 0.852
Structure A0A0H3GLV6
Pocket Pocket 1
ColabFold model
FPocket 0.485 · Pocket 23
P2Rank 0.907 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 21 / 4744 genomes with a hit
Normalized 0.004

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
1 309 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
332 425 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
310 331 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
5 425 PANTHER PTHR30501 UNCHARACTERIZED
5 425 InterPro IPR021144 Uncharacterised protein family UPF0597
145 419 Pfam PF03313 Serine dehydratase alpha chain
145 419 InterPro IPR005130 Serine dehydratase-like, alpha subunit
5 424 Hamap MF_01845 UPF0597 protein YhaM [yhaM].
5 424 InterPro IPR021144 Uncharacterised protein family UPF0597
1 425 PIRSF PIRSF006054 UCP006054
1 425 InterPro IPR021144 Uncharacterised protein family UPF0597

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GLV6
AlphaFold — — full sequence — Viewing
ColabFold KP13_00368
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.505
8 0.187
1 0.141
3 0.016

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 24.32 0.852
2 10.31 0.477
3 2.72 0.066
4 2.37 0.051