Protein profile

KP13_00355

Na/Pi co-transporter II-related protein

Genome: KpKP13

Gene: AHE46906.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GLT6
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Amino acids 543
Annotations 3
Features 44
PDB binders 0
Druggability 0.98

Overview

Basic information about this protein and its source genome.

Accession
KP13_00355
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46906.1
Status
annotated
Amino acids
543
Structure source
AlphaFold + ColabFold
GO
GO:0005436 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in). GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0044341 The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, by a mechanism dependent upon sodium ions.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
88.95

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.98
Structure A0A0H3GLT6
Pocket Pocket 1
P2Rank 0.605
Structure A0A0H3GLT6
Pocket Pocket 1
ColabFold model
FPocket 0.967 · Pocket 20
P2Rank 0.636 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 112 / 4744 genomes with a hit
Normalized 0.024

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005436 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in).
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0044341 The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, by a mechanism dependent upon sodium ions.

Sequence Features

Domain/signature hits from InterPro and related databases.

44 records
Show feature table
Start End DB Term Name
11 300 NCBIfam NF037997 Na/Pi symporter
202 224 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
206 226 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
274 296 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
104 121 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
133 155 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
263 273 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
18 44 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
152 170 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
133 151 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
2 13 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 308 NCBIfam TIGR00704 Na/Pi-cotransporter II-related protein
1 308 InterPro IPR004633 Na/Pi-cotransporter II-related/YqeW-like protein
330 533 Gene3D G3DSA:1.20.58.220 Phosphate transport system protein phou homolog 2; domain 2
330 533 InterPro IPR038078 PhoU-like domain superfamily
1 1 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
175 197 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
122 132 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
4 26 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
14 17 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
239 261 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
159 244 Pfam PF02690 Na+/Pi-cotransporter
159 244 InterPro IPR003841 Sodium-dependent phosphate transport protein
13 147 Pfam PF02690 Na+/Pi-cotransporter
13 147 InterPro IPR003841 Sodium-dependent phosphate transport protein
296 543 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
76 98 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
227 237 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 17 SignalP_EUK SignalP-noTM SignalP-noTM
65 75 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
238 262 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
45 64 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
274 295 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
195 205 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
67 89 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
99 121 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
67 520 NCBIfam TIGR01013 sodium-dependent inorganic phosphate transporter
67 520 InterPro IPR003841 Sodium-dependent phosphate transport protein
171 194 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 102 PANTHER PTHR10010 SOLUTE CARRIER FAMILY 34 SODIUM PHOSPHATE , MEMBER 2-RELATED
1 102 InterPro IPR003841 Sodium-dependent phosphate transport protein
1 17 Phobius SIGNAL_PEPTIDE Signal peptide region
99 103 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
320 531 SUPERFAMILY SSF109755 PhoU-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GLT6
AlphaFold — — full sequence — Viewing
ColabFold KP13_00355
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.98
20 0.818
7 0.202

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 13.15 0.676
2 2.02 0.044
3 1.7 0.03
4 1.53 0.023
5 1.47 0.02