Protein profile

KP13_31742

Homoserine O-succinyltransferase

Genome: KpKP13

Gene: AHE46912.1 metA Structure source: AlphaFold + ColabFold UniProt A0A0H3GKU1
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Amino acids 309
Annotations 5
Features 17
PDB binders 0
Druggability 0.408

Overview

Basic information about this protein and its source genome.

Accession
KP13_31742
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46912.1 metA
Status
annotated
Amino acids
309
Structure source
AlphaFold + ColabFold
EC
2.3.1.46
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0019281 OBSOLETE. The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including homoserine, via the intermediates O-succinyl-L-homoserine and cystathionine. GO:0008899 Catalysis of the reaction: L-homoserine + succinyl-CoA = O-succinyl-L-homoserine + CoA. GO:0004414 Catalysis of the reaction: L-homoserine + acetyl-CoA = O-acetyl-L-homoserine + CoA.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
50.166
DEG E-value
7.42e-111
Localization
Cytoplasmic
ColabFold pLDDT
92.96

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.408
Structure A0A0H3GKU1
Pocket Pocket 8
P2Rank 0.433
Structure A0A0H3GKU1
Pocket Pocket 1
ColabFold model
FPocket 0.695 · Pocket 9
P2Rank 0.539 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 1431 / 4744 genomes with a hit
Normalized 0.302

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0019281 OBSOLETE. The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including homoserine, via the intermediates O-succinyl-L-homoserine and cystathionine.
  • GO:0008899 Catalysis of the reaction: L-homoserine + succinyl-CoA = O-succinyl-L-homoserine + CoA.
  • GO:0004414 Catalysis of the reaction: L-homoserine + acetyl-CoA = O-acetyl-L-homoserine + CoA.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
38 213 CDD cd03131 GATase1_HTS
38 213 InterPro IPR033752 MetA family
2 299 Pfam PF04204 Homoserine O-succinyltransferase
2 299 InterPro IPR033752 MetA family
17 297 SUPERFAMILY SSF52317 Class I glutamine amidotransferase-like
17 297 InterPro IPR029062 Class I glutamine amidotransferase-like
1 308 PIRSF PIRSF000450 HTS
1 308 InterPro IPR033752 MetA family
7 299 Hamap MF_00295 Homoserine O-succinyltransferase [metAS].
7 299 InterPro IPR033752 MetA family
1 305 PANTHER PTHR20919 HOMOSERINE O-SUCCINYLTRANSFERASE
1 305 InterPro IPR033752 MetA family
1 301 FunFam G3DSA:3.40.50.880:FF:000004 Homoserine O-succinyltransferase
1 302 NCBIfam TIGR01001 homoserine O-succinyltransferase
1 302 InterPro IPR005697 Homoserine O-succinyltransferase MetA
1 301 Gene3D G3DSA:3.40.50.880 -
1 301 InterPro IPR029062 Class I glutamine amidotransferase-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GKU1
AlphaFold — — full sequence — Viewing
ColabFold KP13_31742
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
8 0.408

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.83 0.284
2 2.05 0.045
3 2.03 0.044