Protein profile

KP13_01380

Zinc resistance-associated protein

Genome: KpKP13

Gene: AHE46919.1 zraP Structure source: AlphaFold + ColabFold UniProt A0A0H3GQ19
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Amino acids 145
Annotations 1
Features 12
PDB binders 0
Druggability 0.038

Overview

Basic information about this protein and its source genome.

Accession
KP13_01380
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46919.1 zraP
Status
annotated
Amino acids
145
Structure source
AlphaFold + ColabFold
GO
GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
56.911
DEG E-value
4.95e-41
Localization
Periplasmic
ColabFold pLDDT
70.69

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.038
Structure A0A0H3GQ19
Pocket Pocket 9
P2Rank 0.022
Structure A0A0H3GQ19
Pocket Pocket 1
ColabFold model
FPocket 0.346 · Pocket 2
P2Rank 0.207 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 28 / 4744 genomes with a hit
Normalized 0.006

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
19 26 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 6 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 26 Phobius SIGNAL_PEPTIDE Signal peptide region
27 145 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 26 SignalP_EUK SignalP-noTM SignalP-noTM
7 18 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
44 123 Gene3D G3DSA:1.20.120.1490 -
7 26 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
91 111 Coils Coil Coil
1 25 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
6 124 Pfam PF13801 Heavy-metal resistance
6 124 InterPro IPR025961 Heavy-metal resistance protein

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQ19
AlphaFold — — full sequence — Viewing
ColabFold KP13_01380
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer