Protein profile

KP13_01373

Regulator of sigma D

Genome: KpKP13

Gene: rsd AHE46926.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GLR5
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Amino acids 165
Annotations 1
Features 8
PDB binders 0
Druggability 0.581

Overview

Basic information about this protein and its source genome.

Accession
KP13_01373
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
rsd AHE46926.1
Status
annotated
Amino acids
165
Structure source
AlphaFold + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
79.866
DEG E-value
4.67e-88
Localization
Cytoplasmic
ColabFold pLDDT
85.77

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.581
Structure A0A0H3GLR5
Pocket Pocket 9
P2Rank 0.014
Structure A0A0H3GLR5
Pocket Pocket 1
ColabFold model
FPocket 0.465 · Pocket 3
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 91 / 4744 genomes with a hit
Normalized 0.019

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
1 151 Hamap MF_01181 Regulator of sigma D [rsd].
1 151 InterPro IPR023785 Regulator of RNA polymerase sigma(70) subunit, Rsd
1 147 Pfam PF04353 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ
1 147 InterPro IPR007448 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ
1 158 PIRSF PIRSF016548 Rsd_AlgQ
1 158 InterPro IPR007448 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ
1 150 Gene3D G3DSA:1.20.120.1370 Regulator of RNA polymerase sigma(70) subunit, domain 4
1 150 InterPro IPR038309 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GLR5
AlphaFold — — full sequence — Viewing
ColabFold KP13_01373
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
9 0.581
15 0.19
10 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.38 0.014