Protein profile

KP13_01369

Sulfur carrier protein ThiS

Genome: KpKP13

Gene: AHE46930.1 thiS Structure source: AlphaFold + ColabFold UniProt A0A0H3GHA7
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Amino acids 66
Annotations 0
Features 11
PDB binders 0
Druggability 0.312

Overview

Basic information about this protein and its source genome.

Accession
KP13_01369
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46930.1 thiS
Status
annotated
Amino acids
66
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
42.424
DEG E-value
4.67e-10
Localization
Unknown
ColabFold pLDDT
94.39

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.312
Structure A0A0H3GHA7
Pocket Pocket 3
P2Rank
Structure A0A0H3GHA7
Pocket No pockets
ColabFold model
FPocket 0.226 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 69 / 4744 genomes with a hit
Normalized 0.015

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
3 66 CDD cd00565 Ubl_ThiS
6 66 NCBIfam TIGR01683 sulfur carrier protein ThiS
6 66 InterPro IPR010035 ThiS, thiamine-biosynthesis
1 66 SUPERFAMILY SSF54285 MoaD/ThiS
1 66 InterPro IPR016155 Molybdopterin synthase/thiamin biosynthesis sulphur carrier, beta-grasp
5 66 Pfam PF02597 ThiS family
5 66 InterPro IPR003749 Sulfur carrier ThiS/MoaD-like
1 66 Gene3D G3DSA:3.10.20.30 -
1 66 InterPro IPR012675 Beta-grasp domain superfamily
1 66 PANTHER PTHR34472 SULFUR CARRIER PROTEIN THIS
1 66 InterPro IPR010035 ThiS, thiamine-biosynthesis

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GHA7
AlphaFold — — full sequence — Viewing
ColabFold KP13_01369
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.312