Protein profile

KP13_01368

Thiazole synthase

Genome: KpKP13

Gene: AHE46931.1 thiG Structure source: AlphaFold + ColabFold UniProt A0A0H3GLR1
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Amino acids 256
Annotations 1
Features 12
PDB binders 0
Druggability 0.41

Overview

Basic information about this protein and its source genome.

Accession
KP13_01368
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46931.1 thiG
Status
annotated
Amino acids
256
Structure source
AlphaFold + ColabFold
GO
GO:0009228 The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
63.636
DEG E-value
9.04e-116
Localization
Cytoplasmic
ColabFold pLDDT
93.42

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.41
Structure A0A0H3GLR1
Pocket Pocket 2
P2Rank 0.877
Structure A0A0H3GLR1
Pocket Pocket 1
ColabFold model
FPocket 0.552 · Pocket 1
P2Rank 0.824 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 594 / 4744 genomes with a hit
Normalized 0.125

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0009228 The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
2 248 CDD cd04728 ThiG
2 248 InterPro IPR008867 Thiazole synthase
1 255 FunFam G3DSA:3.20.20.70:FF:000049 Thiazole synthase
4 247 Pfam PF05690 Thiazole biosynthesis protein ThiG
4 247 InterPro IPR033983 Thiazole synthase ThiG
1 252 PANTHER PTHR34266 THIAZOLE SYNTHASE
1 252 InterPro IPR008867 Thiazole synthase
1 235 SUPERFAMILY SSF110399 ThiG-like
1 253 Hamap MF_00443 Thiazole synthase [thiG].
1 253 InterPro IPR008867 Thiazole synthase
1 255 Gene3D G3DSA:3.20.20.70 Aldolase class I
1 255 InterPro IPR013785 Aldolase-type TIM barrel

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GLR1
AlphaFold — — full sequence — Viewing
ColabFold KP13_01368
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.41

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 13.24 0.679