Protein profile

KP13_01362

Anaerobic C4-dicarboxylate transporter dcuB

Genome: KpKP13

Gene: AHE46937.1 dcuB Structure source: AlphaFold + ColabFold UniProt A0A0H3GKK4
Export view
Amino acids 446
Annotations 4
Features 42
PDB binders 0
Druggability 0.973

Overview

Basic information about this protein and its source genome.

Accession
KP13_01362
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46937.1 dcuB
Status
annotated
Amino acids
446
Structure source
AlphaFold + ColabFold
GO
GO:0015740 The directed movement of a C4-dicarboxylate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A C4-dicarboxylate is the anion of a dicarboxylic acid that contains four carbon atoms. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015556 Enables the transfer of C4-dicarboxylate from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
68.683
DEG E-value
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
92.88

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.973
Structure A0A0H3GKK4
Pocket Pocket 1
P2Rank 0.892
Structure A0A0H3GKK4
Pocket Pocket 1
ColabFold model
FPocket 0.971 · Pocket 16
P2Rank 0.926 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 258 / 4744 genomes with a hit
Normalized 0.054

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0015740 The directed movement of a C4-dicarboxylate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A C4-dicarboxylate is the anion of a dicarboxylic acid that contains four carbon atoms.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0015556 Enables the transfer of C4-dicarboxylate from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

42 records
Show feature table
Start End DB Term Name
303 325 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
91 117 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
236 255 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
21 43 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
53 75 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
339 355 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
160 170 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
300 318 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
256 266 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
382 420 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
289 299 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
421 443 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
196 235 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
346 368 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
361 381 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
52 71 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
378 400 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
267 288 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
3 442 PANTHER PTHR36106 ANAEROBIC C4-DICARBOXYLATE TRANSPORTER DCUB
3 442 InterPro IPR004668 Anaerobic c4-dicarboxylate membrane transporter
72 90 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
41 51 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
142 164 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
421 445 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
171 195 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
6 376 Pfam PF03605 Anaerobic c4-dicarboxylate membrane transporter
6 376 InterPro IPR004668 Anaerobic c4-dicarboxylate membrane transporter
356 360 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
6 443 NCBIfam TIGR00770 anaerobic C4-dicarboxylate transporter
6 443 InterPro IPR004668 Anaerobic c4-dicarboxylate membrane transporter
1 444 PIRSF PIRSF004539 Anaerob_C4-dicrbxlt_transp
1 444 InterPro IPR004668 Anaerobic c4-dicarboxylate membrane transporter
1 20 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
21 40 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
236 255 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
267 288 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
319 338 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
446 446 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
118 136 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
171 193 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
137 159 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
88 110 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GKK4
AlphaFold — — full sequence — Viewing
ColabFold KP13_01362
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.973
3 0.87
8 0.447

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 21.4 0.869
2 15.99 0.767
3 6.51 0.329
4 3.49 0.128
5 1.76 0.032