Amino acids
121
Annotations
5
Features
23
PDB binders
0
Druggability
0.017
Overview
Basic information about this protein and its source genome.
- Accession
- KP13_01359
- Gene
- AHE46940.1 rplL
- Status
- annotated
- Amino acids
- 121
- Structure source
- AlphaFold + ColabFold
GO
GO:0003735 The action of a molecule that contributes to the structural integrity of the ribosome.
GO:0005840 An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
GO:0006412 The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
GO:0022625 The large subunit of a ribosome located in the cytosol.
GO:0003729 Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
Target profile
Computed evidence for target prioritization.
- Human off-target
- hit
- Human identity (%)
- 38.667
- Human E-value
- 7.16e-06
- Gut microbiome off-target
- hit
- Essential (DEG)
- Y
- DEG identity (%)
- 98.347
- DEG E-value
- 1.83e-75
- Localization
- Unknown
- ColabFold pLDDT
- 75.9
Selected Druggability evidence
AlphaFold / UniProt modelSelected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.
FPocket
0.017
P2Rank
ColabFold model
Core conservation
Conserved core gene
Gut microbiome
2850 / 4744
genomes with a hit
Sequence
Primary amino-acid sequence viewer.
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
5 GO
Gene Ontology (GO)
5- GO:0003735 The action of a molecule that contributes to the structural integrity of the ribosome.
- GO:0005840 An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
- GO:0006412 The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
- GO:0022625 The large subunit of a ribosome located in the cytosol.
- GO:0003729 Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
Sequence Features
Domain/signature hits from InterPro and related databases.
23 records
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 55 | 121 | Pfam | PF00542 | Ribosomal protein L7/L12 C-terminal domain |
| 55 | 121 | InterPro | IPR013823 | Ribosomal protein L7/L12, C-terminal |
| 101 | 121 | Coils | Coil | Coil |
| 6 | 120 | PANTHER | PTHR45987 | 39S RIBOSOMAL PROTEIN L12 |
| 6 | 120 | InterPro | IPR000206 | Ribosomal protein L7/L12 |
| 3 | 120 | CDD | cd00387 | Ribosomal_L7_L12 |
| 3 | 120 | InterPro | IPR000206 | Ribosomal protein L7/L12 |
| 50 | 121 | SUPERFAMILY | SSF54736 | ClpS-like |
| 50 | 121 | InterPro | IPR014719 | Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like |
| 3 | 57 | SUPERFAMILY | SSF48300 | Ribosomal protein L7/12, oligomerisation (N-terminal) domain |
| 3 | 57 | InterPro | IPR036235 | Ribosomal protein L7/L12, oligomerisation domain superfamily |
| 1 | 121 | NCBIfam | TIGR00855 | 50S ribosomal protein L7/L12 |
| 1 | 121 | InterPro | IPR000206 | Ribosomal protein L7/L12 |
| 51 | 121 | FunFam | G3DSA:3.30.1390.10:FF:000001 | 50S ribosomal protein L7/L12 |
| 2 | 50 | Gene3D | G3DSA:1.20.5.710 | Single helix bin |
| 2 | 50 | InterPro | IPR036235 | Ribosomal protein L7/L12, oligomerisation domain superfamily |
| 2 | 50 | FunFam | G3DSA:1.20.5.710:FF:000001 | 50S ribosomal protein L7/L12 |
| 4 | 49 | Pfam | PF16320 | Ribosomal protein L7/L12 dimerisation domain |
| 4 | 49 | InterPro | IPR008932 | Ribosomal protein L7/L12, oligomerisation |
| 51 | 121 | Gene3D | G3DSA:3.30.1390.10 | - |
| 51 | 121 | InterPro | IPR014719 | Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like |
| 2 | 121 | Hamap | MF_00368 | 50S ribosomal protein L7/L12 [rplL]. |
| 2 | 121 | InterPro | IPR000206 | Ribosomal protein L7/L12 |
3D Structure
Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.
Loading 3D structure...
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Structural evidence
0 + 2Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.
| Entry | Method | Resolution | Chain | Coverage | Links | Status |
|---|---|---|---|---|---|---|
|
AlphaFold
AF_A0A0H3GH99
|
AlphaFold | — | — | full sequence | — | Viewing |
|
ColabFold
KP13_01359
|
ColabFold | — | — | full sequence | — | Loaded |
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 3 | 0.506 |