Protein profile

KP13_01358

50S ribosomal protein L10

Genome: KpKP13

Gene: AHE46941.1 rplJ Structure source: AlphaFold + ColabFold UniProt A0A0H3GLQ2
Export view
Amino acids 165
Annotations 4
Features 16
PDB binders 0
Druggability 0.559

Overview

Basic information about this protein and its source genome.

Accession
KP13_01358
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46941.1 rplJ
Status
annotated
Amino acids
165
Structure source
AlphaFold + ColabFold
GO
GO:0003735 The action of a molecule that contributes to the structural integrity of the ribosome. GO:0015934 The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). GO:0006412 The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0070180 Binding to large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
100.0
DEG E-value
2.3800000000000002e-117
Localization
Cytoplasmic
ColabFold pLDDT
72.5

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.559
Structure A0A0H3GLQ2
Pocket Pocket 5
P2Rank 0.189
Structure A0A0H3GLQ2
Pocket Pocket 1
ColabFold model
FPocket 0.893 · Pocket 1
P2Rank 0.037 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 158 / 4744 genomes with a hit
Normalized 0.033

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0003735 The action of a molecule that contributes to the structural integrity of the ribosome.
  • GO:0015934 The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site).
  • GO:0006412 The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
  • GO:0070180 Binding to large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
5 101 Pfam PF00466 Ribosomal protein L10
5 101 InterPro IPR001790 Ribosomal protein L10P
1 130 Gene3D G3DSA:3.30.70.1730 -
1 130 InterPro IPR043141 Ribosomal protein L10-like domain superfamily
3 162 Hamap MF_00362 50S ribosomal protein L10 [rplJ].
3 162 InterPro IPR022973 Ribosomal protein L10
6 157 PANTHER PTHR11560 39S RIBOSOMAL PROTEIN L10, MITOCHONDRIAL
6 157 InterPro IPR001790 Ribosomal protein L10P
4 160 SUPERFAMILY SSF160369 Ribosomal protein L10-like
4 160 InterPro IPR043141 Ribosomal protein L10-like domain superfamily
8 42 ProSitePatterns PS01109 Ribosomal protein L10 signature.
8 42 InterPro IPR002363 Ribosomal protein L10, eubacterial, conserved site
4 160 CDD cd05797 Ribosomal_L10
4 160 InterPro IPR001790 Ribosomal protein L10P
131 165 Gene3D G3DSA:6.10.250.2350 -
1 130 FunFam G3DSA:3.30.70.1730:FF:000001 50S ribosomal protein L10

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GLQ2
AlphaFold — — full sequence — Viewing
ColabFold KP13_01358
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.559
1 0.056
3 0.008
6 0.006

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.03 0.189
2 3.23 0.089
3 2.12 0.04
4 1.32 0.012