Protein profile

KP13_12182

Preprotein translocase subunit secE

Genome: KpKP13

Gene: ANJ86643.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GH93
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Amino acids 127
Annotations 8
Features 31
PDB binders 0
Druggability 0.696

Overview

Basic information about this protein and its source genome.

Accession
KP13_12182
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
ANJ86643.1
Status
annotated
Amino acids
127
Structure source
AlphaFold + ColabFold
GO
GO:0009306 The controlled release of proteins from a cell. GO:0006886 The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006605 The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif. GO:0008320 Enables the transfer of a protein from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
95.276
DEG E-value
1.3999999999999998e-82
Localization
CytoplasmicMembrane
ColabFold pLDDT
82.53

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.696
Structure A0A0H3GH93
Pocket Pocket 3
P2Rank
Structure A0A0H3GH93
Pocket No pockets
ColabFold model
FPocket 0.689 · Pocket 2
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 117 / 4744 genomes with a hit
Normalized 0.025

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

8 GO

Gene Ontology (GO)

8
  • GO:0009306 The controlled release of proteins from a cell.
  • GO:0006886 The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0006605 The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif.
  • GO:0008320 Enables the transfer of a protein from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0065002 The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore.
  • GO:0043952 The process in which unfolded proteins are transported across the cytoplasmic membrane in Gram-positive and Gram-negative bacteria by the Sec complex, in a process involving proteolytic cleavage of an N-terminal signal peptide.

Sequence Features

Domain/signature hits from InterPro and related databases.

31 records
Show feature table
Start End DB Term Name
120 127 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
65 85 PRINTS PR01650 Bacterial translocase SecE signature
65 85 InterPro IPR005807 SecE subunit of protein translocation complex, bacterial-like
109 125 PRINTS PR01650 Bacterial translocase SecE signature
109 125 InterPro IPR005807 SecE subunit of protein translocation complex, bacterial-like
89 109 PRINTS PR01650 Bacterial translocase SecE signature
89 109 InterPro IPR005807 SecE subunit of protein translocation complex, bacterial-like
44 65 PRINTS PR01650 Bacterial translocase SecE signature
44 65 InterPro IPR005807 SecE subunit of protein translocation complex, bacterial-like
95 119 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
41 63 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
24 125 PANTHER PTHR33910 PROTEIN TRANSLOCASE SUBUNIT SECE
24 125 InterPro IPR005807 SecE subunit of protein translocation complex, bacterial-like
70 122 Pfam PF00584 SecE/Sec61-gamma subunits of protein translocation complex
70 122 InterPro IPR001901 Protein translocase complex, SecE/Sec61-gamma subunit
62 94 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
16 36 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
37 42 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
66 122 Gene3D G3DSA:1.20.5.1030 Preprotein translocase secy subunit
66 122 InterPro IPR038379 SecE superfamily
94 116 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
19 36 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 15 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
69 123 NCBIfam TIGR00964 preprotein translocase subunit SecE
69 123 InterPro IPR005807 SecE subunit of protein translocation complex, bacterial-like
67 121 Hamap MF_00422 Protein translocase subunit SecE [secE].
67 121 InterPro IPR001901 Protein translocase complex, SecE/Sec61-gamma subunit
66 122 FunFam G3DSA:1.20.5.1030:FF:000001 Preprotein translocase subunit SecE
71 99 ProSitePatterns PS01067 Protein secE/sec61-gamma signature.
71 99 InterPro IPR001901 Protein translocase complex, SecE/Sec61-gamma subunit
43 61 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GH93
AlphaFold — — full sequence — Viewing
ColabFold KP13_12182
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.696