Protein profile

KP13_01746

Protoporphyrinogen oxidase

Genome: KpKP13

Gene: AHE46951.1 hemG Structure source: AlphaFold + ColabFold UniProt A0A0H3GH88
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Amino acids 177
Annotations 8
Features 14
PDB binders 0
Druggability 0.918

Overview

Basic information about this protein and its source genome.

Accession
KP13_01746
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46951.1 hemG
Status
annotated
Amino acids
177
Structure source
AlphaFold + ColabFold
EC
1.3.5.3
GO
GO:0010181 Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0006783 The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors. GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0006782 The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX. GO:0070819 Catalysis of the reaction: protoporphyrinogen IX + menaquinone = protoporphyrin IX + reduced menaquinone. GO:0004729 Catalysis of the reaction: 3 O2 + protoporphyrinogen IX = 3 H2O2 + protoporphyrin IX.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
75.706
DEG E-value
8.23e-102
Localization
Unknown
ColabFold pLDDT
95.72

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.918
Structure A0A0H3GH88
Pocket Pocket 1
P2Rank 0.153
Structure A0A0H3GH88
Pocket Pocket 1
ColabFold model
FPocket 0.824 · Pocket 1
P2Rank 0.244 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 125 / 4744 genomes with a hit
Normalized 0.026

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 7 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

7
  • GO:0010181 Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
  • GO:0006783 The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.
  • GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways.
  • GO:0006782 The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX.
  • GO:0070819 Catalysis of the reaction: protoporphyrinogen IX + menaquinone = protoporphyrin IX + reduced menaquinone.
  • GO:0004729 Catalysis of the reaction: 3 O2 + protoporphyrinogen IX = 3 H2O2 + protoporphyrin IX.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
4 173 Hamap MF_00853 Protoporphyrinogen IX dehydrogenase [quinone] [hemG].
4 173 InterPro IPR044264 Protoporphyrinogen IX dehydrogenase [quinone] HemG
1 177 Gene3D G3DSA:3.40.50.360 -
1 177 InterPro IPR029039 Flavoprotein-like superfamily
1 173 SUPERFAMILY SSF52218 Flavoproteins
1 173 InterPro IPR029039 Flavoprotein-like superfamily
4 152 Pfam PF12724 Flavodoxin domain
4 152 InterPro IPR026816 Flavodoxin domain
2 174 FunFam G3DSA:3.40.50.360:FF:000017 Protoporphyrinogen oxidase (PPO)
1 173 PANTHER PTHR38030 PROTOPORPHYRINOGEN IX DEHYDROGENASE [MENAQUINONE]
5 21 ProSitePatterns PS00201 Flavodoxin signature.
5 21 InterPro IPR001226 Flavodoxin, conserved site
3 177 ProSiteProfiles PS50902 Flavodoxin-like domain profile.
3 177 InterPro IPR008254 Flavodoxin/nitric oxide synthase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GH88
AlphaFold — — full sequence — Viewing
ColabFold KP13_01746
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.918

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.5 0.069