Protein profile

KP13_01744

IMPACT family member

Genome: KpKP13

Gene: AHE46953.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GKH7
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Amino acids 204
Annotations 5
Features 17
PDB binders 1
Druggability 0.486

Overview

Basic information about this protein and its source genome.

Accession
KP13_01744
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46953.1
Status
annotated
Amino acids
204
Structure source
AlphaFold + ColabFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0043168 Binding to an anion, a charged atom or group of atoms with a net negative charge. GO:0032561 Binding to a guanyl ribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety. GO:0017111 Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate. GO:0006446 Any process that modulates the frequency, rate or extent of translational initiation.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
95.45

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.486
Structure A0A0H3GKH7
Pocket Pocket 5
P2Rank
Structure A0A0H3GKH7
Pocket No pockets
ColabFold model
FPocket 0.451 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 143 / 4744 genomes with a hit
Normalized 0.03

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0043168 Binding to an anion, a charged atom or group of atoms with a net negative charge.
  • GO:0032561 Binding to a guanyl ribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.
  • GO:0017111 Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate.
  • GO:0006446 Any process that modulates the frequency, rate or extent of translational initiation.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
4 172 PANTHER PTHR16301 IMPACT-RELATED
4 172 InterPro IPR023582 Impact family
18 125 Pfam PF01205 Uncharacterized protein family UPF0029
18 125 InterPro IPR001498 Impact, N-terminal
1 132 Gene3D G3DSA:3.30.230.30 -
1 132 InterPro IPR036956 Impact, N-terminal domain superfamily
136 203 SUPERFAMILY SSF54980 EF-G C-terminal domain-like
136 203 InterPro IPR035647 EF-G domain III/V-like
3 131 SUPERFAMILY SSF54211 Ribosomal protein S5 domain 2-like
3 131 InterPro IPR020568 Ribosomal protein S5 domain 2-type fold
80 109 ProSitePatterns PS00910 Uncharacterized protein family UPF0029 signature.
80 109 InterPro IPR020569 Uncharacterised protein family UPF0029, Impact, conserved site
141 195 Pfam PF09186 Domain of unknown function (DUF1949)
141 195 InterPro IPR015269 Uncharacterised domain UPF0029, Impact, C-terminal
133 204 Gene3D G3DSA:3.30.70.240 -
1 203 NCBIfam TIGR00257 YigZ family protein
1 203 InterPro IPR015796 Impact YigZ-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GKH7
AlphaFold — — full sequence — Viewing
ColabFold KP13_01744
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.431
4 0.027
7 0.024
2 0.022

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

16 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
TLA
2CVE
Q5SJF5 150.1 Da LogP -2.12 TPSA 115.1 ✓ Ro5 ✓ Clean [C@@H]([C@H](C(=O)O)O)(C(=O)O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.