Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: KP13_01734
Assembly: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene: AHE46963.1 tatA
Status: annotated
Amino acids: 83
Structure source: AlphaFold + ColabFold

GO

GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0043953 The process in which folded proteins are transported across cytoplasmic membranes of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) by the TAT complex. GO:0033281 A complex of three proteins integral to the cytoplasmic membrane of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) involved in membrane transport of folded proteins. GO:0008320 Enables the transfer of a protein from one side of a membrane to the other. GO:0065002 The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Human identity (%): 0.0
Gut microbiome off-target: hit
Essential (DEG): Y
DEG identity (%): 42.308
DEG E-value: 1.01e-10
Localization: CytoplasmicMembrane
ColabFold pLDDT: 74.9

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.043

Structure A0A0H3GGL3

Pocket Pocket 2

P2Rank

Structure A0A0H3GGL3

Pocket No pockets

ColabFold model

FPocket 0.108 · Pocket 1

Core conservation Accessory gene

Roary core

CoreCruncher accessory

Gut microbiome 144 / 4744 genomes with a hit

Normalized 0.03

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6

GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0043953 The process in which folded proteins are transported across cytoplasmic membranes of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) by the TAT complex.
GO:0033281 A complex of three proteins integral to the cytoplasmic membrane of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) involved in membrane transport of folded proteins.
GO:0008320 Enables the transfer of a protein from one side of a membrane to the other.
GO:0065002 The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records

Show feature table

Start	End	DB	Term	Name
6	22	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	5	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1	81	PANTHER	PTHR42982	SEC-INDEPENDENT PROTEIN TRANSLOCASE PROTEIN TATA
1	47	Gene3D	G3DSA:1.20.5.3310	-
4	50	Pfam	PF02416	mttA/Hcf106 family
4	50	InterPro	IPR003369	Sec-independent protein translocase protein TatA/B/E
23	83	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
4	21	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
44	83	MobiDBLite	mobidb-lite	consensus disorder prediction
1	47	FunFam	G3DSA:1.20.5.3310:FF:000001	Probable Sec-independent protein translocase protein TatE
3	48	NCBIfam	TIGR01411	twin-arginine translocase TatA/TatE family subunit
3	48	InterPro	IPR006312	Sec-independent protein translocase protein TatA/E
1	81	Hamap	MF_00236	Sec-independent protein translocase protein TatA [tatA].
1	81	InterPro	IPR006312	Sec-independent protein translocase protein TatA/E

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

No pockets are loaded yet for the displayed AlphaFold model AF_A0A0H3GGL3 structure. Run experimental pocket backfill to show FPocket/P2Rank overlays on this structure.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_A0A0H3GGL3	AlphaFold	—	—	full sequence	—	Viewing
ColabFold KP13_01734	ColabFold	—	—	full sequence	—	Loaded

KP13_01734