Protein profile

KP13_01732

SCP2 sterol-binding domain-containing protein

Genome: KpKP13

Gene: AHE46965.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GH75
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Amino acids 201
Annotations 3
Features 9
PDB binders 1
Druggability 0.893

Overview

Basic information about this protein and its source genome.

Accession
KP13_01732
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46965.1
Status
annotated
Amino acids
201
Structure source
AlphaFold + ColabFold
GO
GO:0032150 OBSOLETE. The chemical reactions and pathways resulting in the formation of ubiquinone, beginning with the conversion of chorismate to 4-hydroxybenzoate. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0006744 The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
76.119
DEG E-value
5.67e-111
Localization
Cytoplasmic
ColabFold pLDDT
74.77

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.893
Structure A0A0H3GH75
Pocket Pocket 5
P2Rank 0.852
Structure A0A0H3GH75
Pocket Pocket 1
ColabFold model
FPocket 0.84 · Pocket 1
P2Rank 0.824 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 95 / 4744 genomes with a hit
Normalized 0.02

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0032150 OBSOLETE. The chemical reactions and pathways resulting in the formation of ubiquinone, beginning with the conversion of chorismate to 4-hydroxybenzoate.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0006744 The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
181 201 Coils Coil Coil
5 201 Hamap MF_02215 Ubiquinone biosynthesis accessory factor UbiJ [ubiJ].
5 201 InterPro IPR038989 Ubiquinone biosynthesis accessory factor UbiJ
11 113 SUPERFAMILY SSF55718 SCP-like
11 113 InterPro IPR036527 SCP2 sterol-binding domain superfamily
2 201 PANTHER PTHR38693 UBIQUINONE BIOSYNTHESIS PROTEIN UBIJ
2 201 InterPro IPR038989 Ubiquinone biosynthesis accessory factor UbiJ
15 112 Pfam PF02036 SCP-2 sterol transfer family
15 112 InterPro IPR003033 SCP2 sterol-binding domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GH75
AlphaFold — — full sequence — Viewing
ColabFold KP13_01732
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.893

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 15.24 0.75

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

7 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
LMR
6H6O
P0ADP7 134.1 Da LogP -1.09 TPSA 94.8 ✓ Ro5 ✓ Clean C([C@@H](C(=O)O)O)C(=O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.