Protein profile

KP13_01730

DNA recombination protein rmuC

Genome: KpKP13

Gene: AHE46967.1 rmuC Structure source: AlphaFold + ColabFold UniProt A0A0H3GKG3
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Amino acids 482
Annotations 1
Features 15
PDB binders 0
Druggability 0.594

Overview

Basic information about this protein and its source genome.

Accession
KP13_01730
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46967.1 rmuC
Status
annotated
Amino acids
482
Structure source
AlphaFold + ColabFold
GO
GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
88.937
DEG E-value
0.0
Localization
Unknown
ColabFold pLDDT
81.47

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.594
Structure A0A0H3GKG3
Pocket Pocket 38
P2Rank 0.006
Structure A0A0H3GKG3
Pocket Pocket 1
ColabFold model
FPocket 0.742 · Pocket 49
P2Rank 0.03 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 120 / 4744 genomes with a hit
Normalized 0.025

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
32 52 Coils Coil Coil
168 195 Coils Coil Coil
24 28 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
7 456 PANTHER PTHR30563 DNA RECOMBINATION PROTEIN RMUC
7 456 InterPro IPR003798 DNA recombination RmuC
5 23 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
5 24 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
63 90 Coils Coil Coil
1 28 Phobius SIGNAL_PEPTIDE Signal peptide region
444 482 MobiDBLite mobidb-lite consensus disorder prediction
137 433 Pfam PF02646 RmuC family
137 433 InterPro IPR003798 DNA recombination RmuC
102 122 Coils Coil Coil
1 4 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
29 482 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GKG3
AlphaFold — — full sequence — Viewing
ColabFold KP13_01730
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
38 0.594
3 0.001
27 0.0
34 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.07 0.006