Protein profile

KP13_01728

Putative carboxymethylenebutenolidase

Genome: KpKP13

Gene: AHE46968.1 Structure source: AlphaFold + ColabFold UniProt W8V231
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Amino acids 319
Annotations 3
Features 7
PDB binders 0
Druggability 0.991

Overview

Basic information about this protein and its source genome.

Accession
KP13_01728
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46968.1
Status
annotated
Amino acids
319
Structure source
AlphaFold + ColabFold
EC
3.1.1.45
GO
GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0008806 Catalysis of the reaction: 4-carboxymethylenebut-2-en-4-olide + H2O = 4 oxohex-2-enedioate.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
25.405
Human E-value
7.08e-08
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
85.7

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.991
Structure W8V231
Pocket Pocket 5
P2Rank 0.884
Structure W8V231
Pocket Pocket 1
ColabFold model
FPocket 0.739 · Pocket 5
P2Rank 0.837 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 98 / 4744 genomes with a hit
Normalized 0.021

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 2 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

2
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
  • GO:0008806 Catalysis of the reaction: 4-carboxymethylenebut-2-en-4-olide + H2O = 4 oxohex-2-enedioate.

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
91 314 Pfam PF01738 Dienelactone hydrolase family
91 314 InterPro IPR002925 Dienelactone hydrolase
75 314 Gene3D G3DSA:3.40.50.1820 alpha/beta hydrolase
75 314 InterPro IPR029058 Alpha/Beta hydrolase fold
82 313 SUPERFAMILY SSF53474 alpha/beta-Hydrolases
82 313 InterPro IPR029058 Alpha/Beta hydrolase fold
78 314 PANTHER PTHR46623 CARBOXYMETHYLENEBUTENOLIDASE-RELATED

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_W8V231
AlphaFold — — full sequence — Viewing
ColabFold KP13_01728
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.991

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 18.07 0.814
2 1.79 0.033