Protein profile

KP13_01722

Homoserine/homoserine lactone efflux protein

Genome: KpKP13

Gene: AHE46974.1 rhtB Structure source: AlphaFold + ColabFold UniProt A0A0H3GPX1
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Amino acids 206
Annotations 4
Features 27
PDB binders 0
Druggability 0.799

Overview

Basic information about this protein and its source genome.

Accession
KP13_01722
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46974.1 rhtB
Status
annotated
Amino acids
206
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006865 The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0042970 Enables the transfer of homoserine from one side of a membrane to the other. Homoserine is alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
86.7

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.799
Structure A0A0H3GPX1
Pocket Pocket 4
P2Rank 0.809
Structure A0A0H3GPX1
Pocket Pocket 1
ColabFold model
FPocket 0.998 · Pocket 3
P2Rank 0.737 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 99 / 4744 genomes with a hit
Normalized 0.021

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0006865 The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0042970 Enables the transfer of homoserine from one side of a membrane to the other. Homoserine is alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine.

Sequence Features

Domain/signature hits from InterPro and related databases.

27 records
Show feature table
Start End DB Term Name
24 38 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 24 SignalP_EUK SignalP-TM SignalP-TM
116 138 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
39 65 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
14 202 Pfam PF01810 LysE type translocator
14 202 InterPro IPR001123 Amino acid exporter protein, LeuE-type
1 23 Phobius SIGNAL_PEPTIDE Signal peptide region
169 187 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
206 206 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 204 PANTHER PTHR30086 ARGININE EXPORTER PROTEIN ARGO
1 204 InterPro IPR001123 Amino acid exporter protein, LeuE-type
1 6 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
66 115 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
188 205 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
7 18 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
7 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 205 PIRSF PIRSF006324 LeuE
1 205 InterPro IPR001123 Amino acid exporter protein, LeuE-type
115 137 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
19 200 NCBIfam TIGR00949 homoserine/threonine efflux transporter
19 200 InterPro IPR004778 Homoserine/Threonine efflux protein
139 143 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
19 23 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
147 169 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
188 205 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
44 66 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
144 168 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GPX1
AlphaFold — — full sequence — Viewing
ColabFold KP13_01722
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.799
3 0.579
6 0.299

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 12.26 0.645
2 3.31 0.117
3 2.43 0.066
4 2.25 0.055
5 1.13 0.008