Protein profile

KP13_01717

Thioesterase domain-containing protein

Genome: KpKP13

Gene: AHE46979.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GPW6
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Amino acids 154
Annotations 2
Features 9
PDB binders 0
Druggability 0.195

Overview

Basic information about this protein and its source genome.

Accession
KP13_01717
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46979.1
Status
annotated
Amino acids
154
Structure source
AlphaFold + ColabFold
EC
3.1.2.20
GO
GO:0047617 Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
96.43

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.195
Structure A0A0H3GPW6
Pocket Pocket 1
P2Rank 0.181
Structure A0A0H3GPW6
Pocket Pocket 1
ColabFold model
FPocket 0.366 · Pocket 1
P2Rank 0.214 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 104 / 4744 genomes with a hit
Normalized 0.022

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 1 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

1
  • GO:0047617 Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
24 152 PANTHER PTHR43240 1,4-DIHYDROXY-2-NAPHTHOYL-COA THIOESTERASE 1
56 144 Pfam PF03061 Thioesterase superfamily
56 144 InterPro IPR006683 Thioesterase domain
26 153 CDD cd03443 PaaI_thioesterase
24 152 NCBIfam TIGR00369 hotdog fold thioesterase
24 152 InterPro IPR003736 Phenylacetic acid degradation-related domain
1 154 Gene3D G3DSA:3.10.129.10 Hotdog Thioesterase
8 153 SUPERFAMILY SSF54637 Thioesterase/thiol ester dehydrase-isomerase
8 153 InterPro IPR029069 HotDog domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GPW6
AlphaFold — — full sequence — Viewing
ColabFold KP13_01717
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.77 0.145