Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: KP13_01708
Assembly: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene: cyaY AHE46987.1
Status: annotated
Amino acids: 106
Structure source: AlphaFold + ColabFold

GO

GO:0008199 Binding to a ferric iron ion, Fe(III). GO:0016226 The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008198 Binding to a ferrous iron ion, Fe(II).

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Human identity (%): 0.0
Gut microbiome off-target: hit
Essential (DEG): Y
DEG identity (%): 42.857
DEG E-value: 7.32e-27
Localization: Cytoplasmic
ColabFold pLDDT: 95.9

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.07

Structure A0A0H3GPW0

Pocket Pocket 4

P2Rank

Structure A0A0H3GPW0

Pocket No pockets

ColabFold model

FPocket 0.3 · Pocket 1

Core conservation Conserved core gene

Roary core

CoreCruncher core

Gut microbiome 107 / 4744 genomes with a hit

Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4

GO:0008199 Binding to a ferric iron ion, Fe(III).
GO:0016226 The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GO:0008198 Binding to a ferrous iron ion, Fe(II).

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records

Show feature table

Start	End	DB	Term	Name
1	102	Pfam	PF01491	Frataxin-like domain
1	102	InterPro	IPR002908	Frataxin/CyaY
1	105	PANTHER	PTHR16821	FRATAXIN
1	105	InterPro	IPR002908	Frataxin/CyaY
1	105	Hamap	MF_00142	Iron-sulfur cluster assembly protein CyaY [cyaY].
1	105	InterPro	IPR047584	Iron-sulfur cluster assembly protein CyaY
1	105	SUPERFAMILY	SSF55387	Frataxin/Nqo15-like
1	105	InterPro	IPR036524	Frataxin/CyaY superfamily
1	106	Gene3D	G3DSA:3.30.920.10	Frataxin/CyaY
1	106	InterPro	IPR036524	Frataxin/CyaY superfamily
1	103	ProSiteProfiles	PS50810	Frataxin family profile.
1	103	InterPro	IPR002908	Frataxin/CyaY
50	64	ProSitePatterns	PS01344	Frataxin family signature.
50	64	InterPro	IPR020895	Frataxin conserved site
1	106	SMART	SM01219	Frataxin_Cyay_2
1	106	InterPro	IPR002908	Frataxin/CyaY
1	106	FunFam	G3DSA:3.30.920.10:FF:000001	Iron-sulfur cluster assembly protein CyaY
2	105	NCBIfam	TIGR03421	iron donor protein CyaY
2	105	InterPro	IPR002908	Frataxin/CyaY
1	105	CDD	cd00503	Frataxin

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_A0A0H3GPW0	AlphaFold	—	—	full sequence	—	Viewing
ColabFold KP13_01708	ColabFold	—	—	full sequence	—	Loaded

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.3

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

1 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

No PDB structure with a co-crystallized ligand found for this exact protein.

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Ligand	Source crystal	UniProt (homolog)	MW · LogP · TPSA	Lipinski	PAINS	SMILES
EU3	4LP1	A1SR01	152.0 Da LogP 0.00 TPSA 0.0	✓ Ro5	✓ Clean	`[Eu+3]`

Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL bioactivity data found for this exact protein.

Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL hits found through similar proteins.

Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).

No virtual-screening candidates for this protein.

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.

KP13_01708