Protein profile

KP13_13238

Adenylate cyclase

Genome: KpKP13

Gene: ANJ86646.1 cyaA Structure source: AlphaFold + ColabFold UniProt A0A0H3GH51
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Amino acids 850
Annotations 5
Features 12
PDB binders 0
Druggability 0.887

Overview

Basic information about this protein and its source genome.

Accession
KP13_13238
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
ANJ86646.1 cyaA
Status
annotated
Amino acids
850
Structure source
AlphaFold + ColabFold
EC
4.6.1.1
GO
GO:0006171 The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). GO:0004016 Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
93.059
DEG E-value
0.0
Localization
Cytoplasmic
ColabFold pLDDT
82.63

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.887
Structure A0A0H3GH51
Pocket Pocket 13
P2Rank 0.766
Structure A0A0H3GH51
Pocket Pocket 1
ColabFold model
FPocket 0.161 · Pocket 52
P2Rank 0.81 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 121 / 4744 genomes with a hit
Normalized 0.026

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0006171 The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).
  • GO:0004016 Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
228 826 Pfam PF01295 Adenylate cyclase, class-I
228 826 InterPro IPR000274 Adenylate cyclase, class-I
5 200 Pfam PF12633 Adenylate cyclase NT domain
5 200 InterPro IPR024685 Adenylate cyclase class-I, N-terminal domain
598 612 ProSitePatterns PS01093 Adenylate cyclase class-I signature 2.
598 612 InterPro IPR024686 Adenylate cyclase class-I, conserved site
1 841 PANTHER PTHR38760 ADENYLATE CYCLASE
1 841 InterPro IPR000274 Adenylate cyclase, class-I
1 849 PIRSF PIRSF001444 Adenylate_cycl
1 849 InterPro IPR000274 Adenylate cyclase, class-I
242 253 ProSitePatterns PS01092 Adenylate cyclase class-I signature 1.
242 253 InterPro IPR024686 Adenylate cyclase class-I, conserved site

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GH51
AlphaFold — — full sequence — Viewing
ColabFold KP13_13238
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
13 0.887
60 0.494
3 0.205

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 10.72 0.575
2 8.49 0.453
3 4.64 0.202
4 3.38 0.121
5 2.58 0.073