Protein profile

KP13_01705

Uroporphyrinogen-III synthase

Genome: KpKP13

Gene: AHE46989.1 hemD Structure source: AlphaFold + ColabFold UniProt A0A0H3GGJ2
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Amino acids 246
Annotations 5
Features 12
PDB binders 0
Druggability 0.575

Overview

Basic information about this protein and its source genome.

Accession
KP13_01705
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46989.1 hemD
Status
annotated
Amino acids
246
Structure source
AlphaFold + ColabFold
EC
4.2.1.75
GO
GO:0006780 The chemical reactions and pathways resulting in the formation of uroporphyrinogen III. GO:0033014 The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. GO:0004852 Catalysis of the reaction: hydroxymethylbilane = H2O + uroporphyrinogen III. GO:0006782 The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
80.894
DEG E-value
1.0700000000000001e-144
Localization
Unknown
ColabFold pLDDT
95.28

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.575
Structure A0A0H3GGJ2
Pocket Pocket 4
P2Rank 0.022
Structure A0A0H3GGJ2
Pocket Pocket 1
ColabFold model
FPocket 0.336 · Pocket 4
P2Rank 0.072 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 98 / 4744 genomes with a hit
Normalized 0.021

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0006780 The chemical reactions and pathways resulting in the formation of uroporphyrinogen III.
  • GO:0033014 The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.
  • GO:0004852 Catalysis of the reaction: hydroxymethylbilane = H2O + uroporphyrinogen III.
  • GO:0006782 The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
14 242 Pfam PF02602 Uroporphyrinogen-III synthase HemD
14 242 InterPro IPR003754 Tetrapyrrole biosynthesis, uroporphyrinogen III synthase
2 245 PANTHER PTHR38042 UROPORPHYRINOGEN-III SYNTHASE, CHLOROPLASTIC
2 245 InterPro IPR039793 Uroporphyrinogen-III synthase
1 245 SUPERFAMILY SSF69618 HemD-like
1 245 InterPro IPR036108 Tetrapyrrole biosynthesis, uroporphyrinogen III synthase superfamily
3 245 CDD cd06578 HemD
3 245 InterPro IPR003754 Tetrapyrrole biosynthesis, uroporphyrinogen III synthase
3 245 Gene3D G3DSA:3.40.50.10090 -
3 245 InterPro IPR036108 Tetrapyrrole biosynthesis, uroporphyrinogen III synthase superfamily
32 165 Gene3D G3DSA:3.40.50.10090 -
32 165 InterPro IPR036108 Tetrapyrrole biosynthesis, uroporphyrinogen III synthase superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GGJ2
AlphaFold — — full sequence — Viewing
ColabFold KP13_01705
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.575
2 0.102
1 0.008
7 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.64 0.022