Protein profile

KP13_01704

Putative uroporphyrinogen-III C-methyltransferase

Genome: KpKP13

Gene: AHE46990.1 hemX Structure source: AlphaFold + ColabFold UniProt A0A0H3GPV6
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Amino acids 393
Annotations 2
Features 12
PDB binders 0
Druggability 0.448

Overview

Basic information about this protein and its source genome.

Accession
KP13_01704
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46990.1 hemX
Status
annotated
Amino acids
393
Structure source
AlphaFold + ColabFold
GO
GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0032259 The process in which a methyl group is covalently attached to a molecule.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
73.69

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.448
Structure A0A0H3GPV6
Pocket Pocket 1
P2Rank
Structure A0A0H3GPV6
Pocket No pockets
ColabFold model
FPocket 0.232 · Pocket 7
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 107 / 4744 genomes with a hit
Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule.
  • GO:0032259 The process in which a methyl group is covalently attached to a molecule.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
1 373 PANTHER PTHR38043 PROTEIN HEMX
1 373 InterPro IPR007470 Putative uroporphyrinogen-III C-methyltransferase HemX
369 393 MobiDBLite mobidb-lite consensus disorder prediction
1 37 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
88 122 Coils Coil Coil
18 32 MobiDBLite mobidb-lite consensus disorder prediction
1 32 MobiDBLite mobidb-lite consensus disorder prediction
59 393 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
36 58 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
131 364 Pfam PF04375 HemX, putative uroporphyrinogen-III C-methyltransferase
131 364 InterPro IPR007470 Putative uroporphyrinogen-III C-methyltransferase HemX
38 58 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GPV6
AlphaFold — — full sequence — Viewing
ColabFold KP13_01704
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.448