Protein profile

KP13_01703

Protein hemY

Genome: KpKP13

Gene: hemY AHE46991.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GH46
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Amino acids 398
Annotations 5
Features 24
PDB binders 0
Druggability 0.844

Overview

Basic information about this protein and its source genome.

Accession
KP13_01703
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
hemY AHE46991.1
Status
annotated
Amino acids
398
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005515 Binding to a protein. GO:0042168 The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0006779 The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
89.15

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.844
Structure A0A0H3GH46
Pocket Pocket 7
P2Rank 0.04
Structure A0A0H3GH46
Pocket Pocket 1
ColabFold model
FPocket 0.953 · Pocket 1
P2Rank 0.059 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 109 / 4744 genomes with a hit
Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0005515 Binding to a protein.
  • GO:0042168 The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0006779 The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group.

Sequence Features

Domain/signature hits from InterPro and related databases.

24 records
Show feature table
Start End DB Term Name
5 27 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 18 SignalP_EUK SignalP-TM SignalP-TM
328 361 ProSiteProfiles PS50005 TPR repeat profile.
328 361 InterPro IPR019734 Tetratricopeptide repeat
1 26 Phobius SIGNAL_PEPTIDE Signal peptide region
71 296 Gene3D G3DSA:1.25.40.10 Tetratricopeptide repeat domain
71 296 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
304 396 Gene3D G3DSA:1.25.40.10 Tetratricopeptide repeat domain
304 396 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
26 132 Pfam PF07219 HemY protein N-terminus
26 132 InterPro IPR010817 HemY, N-terminal
97 382 SUPERFAMILY SSF48452 TPR-like
97 382 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
27 41 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
40 62 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
18 26 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
4 17 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
329 360 Pfam PF07719 Tetratricopeptide repeat
329 360 InterPro IPR013105 Tetratricopeptide repeat 2
42 62 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
63 398 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
4 386 NCBIfam TIGR00540 heme biosynthesis-associated TPR protein
4 386 InterPro IPR005254 Heme biosynthesis-associated TPR protein

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GH46
AlphaFold — — full sequence — Viewing
ColabFold KP13_01703
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.844