Protein profile

KP13_01695

Lipopolysaccharide biosynthesis protein rffC

Genome: KpKP13

Gene: AHE46999.1 rffC Structure source: AlphaFold + ColabFold UniProt A0A0H3GGI2
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Amino acids 224
Annotations 4
Features 10
PDB binders 0
Druggability 0.814

Overview

Basic information about this protein and its source genome.

Accession
KP13_01695
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46999.1 rffC
Status
annotated
Amino acids
224
Structure source
AlphaFold + ColabFold
EC
2.3.1.210
GO
GO:0008080 Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. GO:0009246 The chemical reactions and pathways resulting in the formation of the enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria. GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
51.25
DEG E-value
9.32e-71
Localization
Unknown
ColabFold pLDDT
97.61

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.814
Structure A0A0H3GGI2
Pocket Pocket 1
P2Rank 0.867
Structure A0A0H3GGI2
Pocket Pocket 1
ColabFold model
FPocket 0.492 · Pocket 3
P2Rank 0.885 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 88 / 4744 genomes with a hit
Normalized 0.019

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 3 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

3
  • GO:0008080 Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule.
  • GO:0009246 The chemical reactions and pathways resulting in the formation of the enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria.
  • GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
44 224 Hamap MF_02027 dTDP-fucosamine acetyltransferase [wecD].
44 224 InterPro IPR012752 dTDP-fucosamine acetyltransferase WecD
91 224 ProSiteProfiles PS51186 Gcn5-related N-acetyltransferase (GNAT) domain profile.
91 224 InterPro IPR000182 GNAT domain
1 224 FunFam G3DSA:3.40.630.30:FF:000044 dTDP-fucosamine acetyltransferase
44 224 NCBIfam TIGR02382 dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase
96 218 PANTHER PTHR43877 -
1 224 Gene3D G3DSA:3.40.630.30 -
43 208 SUPERFAMILY SSF55729 Acyl-CoA N-acyltransferases (Nat)
43 208 InterPro IPR016181 Acyl-CoA N-acyltransferase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GGI2
AlphaFold — — full sequence — Viewing
ColabFold KP13_01695
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.814

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 17.37 0.801
2 3.71 0.141
3 1.02 0.006