Protein profile

KP13_01691

UDP-N-acetylglucosamine 2-epimerase

Genome: KpKP13

Gene: AHE47002.1 wecB Structure source: AlphaFold + ColabFold UniProt A0A0H3GKC6
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Amino acids 376
Annotations 4
Features 13
PDB binders 1
Druggability 0.306

Overview

Basic information about this protein and its source genome.

Accession
KP13_01691
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47002.1 wecB
Status
annotated
Amino acids
376
Structure source
AlphaFold + ColabFold
EC
5.1.3.14
GO
GO:0009246 The chemical reactions and pathways resulting in the formation of the enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria. GO:0008761 Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
21.975
Human E-value
2e-07
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
83.245
DEG E-value
0.0
Localization
Cytoplasmic
ColabFold pLDDT
95.38

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.306
Structure A0A0H3GKC6
Pocket Pocket 24
P2Rank 0.983
Structure A0A0H3GKC6
Pocket Pocket 1
ColabFold model
FPocket 0.478 · Pocket 5
P2Rank 0.825 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 1343 / 4744 genomes with a hit
Normalized 0.283

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 3 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

3
  • GO:0009246 The chemical reactions and pathways resulting in the formation of the enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria.
  • GO:0008761 Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
2 191 FunFam G3DSA:3.40.50.2000:FF:000043 UDP-N-acetylglucosamine 2-epimerase
1 372 NCBIfam TIGR00236 UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing)
1 372 InterPro IPR029767 UDP-N-acetylglucosamine 2-epimerase WecB-like
1 374 PANTHER PTHR43174 UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE
1 374 InterPro IPR029767 UDP-N-acetylglucosamine 2-epimerase WecB-like
2 370 CDD cd03786 GTB_UDP-GlcNAc_2-Epimerase
187 356 Gene3D G3DSA:3.40.50.2000 Glycogen Phosphorylase B;
22 370 Pfam PF02350 UDP-N-acetylglucosamine 2-epimerase
22 370 InterPro IPR003331 UDP-N-acetylglucosamine 2-epimerase domain
1 371 SUPERFAMILY SSF53756 UDP-Glycosyltransferase/glycogen phosphorylase
16 374 Hamap MF_02028 UDP-N-acetylglucosamine 2-epimerase [wecB].
16 374 InterPro IPR032892 UDP-N-acetylglucosamine 2-epimerase WecB
2 366 Gene3D G3DSA:3.40.50.2000 Glycogen Phosphorylase B;

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GKC6
AlphaFold — — full sequence — Viewing
ColabFold KP13_01691
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
24 0.306

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 25.02 0.903
2 10.9 0.585
3 6.83 0.35
4 3.23 0.111

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

51 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
UD1
6VLC
A0A0U1RGY0 607.4 Da LogP -4.65 TPSA 305.9 3 viol. ✓ Clean CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@@H]1O[P@@]…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.