Protein profile

KP13_00576

Cell division protein ftsN

Genome: KpKP13

Gene: ftsN AHE47051.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GGY9
Export view
Amino acids 284
Annotations 6
Features 23
PDB binders 0
Druggability 0.481

Overview

Basic information about this protein and its source genome.

Accession
KP13_00576
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
ftsN AHE47051.1
Status
annotated
Amino acids
284
Structure source
AlphaFold + ColabFold
GO
GO:0005515 Binding to a protein. GO:0042834 Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls. GO:0032153 The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0000917 The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a division septum are not able to exchange intracellular material. GO:0043093 A cytokinesis process that involves a set of conserved proteins including FtsZ, and results in the formation of two similarly sized and shaped cells.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
71.284
DEG E-value
1.31e-134
Localization
CytoplasmicMembrane
ColabFold pLDDT
69.96

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.481
Structure A0A0H3GGY9
Pocket Pocket 27
P2Rank
Structure A0A0H3GGY9
Pocket No pockets
ColabFold model
FPocket 0.649 · Pocket 4
P2Rank 0.017 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 79 / 4744 genomes with a hit
Normalized 0.017

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0005515 Binding to a protein.
  • GO:0042834 Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls.
  • GO:0032153 The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0000917 The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a division septum are not able to exchange intracellular material.
  • GO:0043093 A cytokinesis process that involves a set of conserved proteins including FtsZ, and results in the formation of two similarly sized and shaped cells.

Sequence Features

Domain/signature hits from InterPro and related databases.

23 records
Show feature table
Start End DB Term Name
145 191 MobiDBLite mobidb-lite consensus disorder prediction
204 284 Gene3D G3DSA:3.30.70.1070 Sporulation related repeat
204 284 InterPro IPR036680 Sporulation-like domain superfamily
82 121 MobiDBLite mobidb-lite consensus disorder prediction
211 277 Pfam PF05036 SPOR domain
211 277 InterPro IPR007730 Sporulation-like domain
1 280 NCBIfam TIGR02223 cell division protein FtsN
1 280 InterPro IPR011930 Cell division protein FtsN
1 18 Phobius SIGNAL_PEPTIDE Signal peptide region
2 13 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
209 279 SUPERFAMILY SSF110997 Sporulation related repeat
209 279 InterPro IPR036680 Sporulation-like domain superfamily
2 21 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
55 121 MobiDBLite mobidb-lite consensus disorder prediction
1 282 PANTHER PTHR38687 CELL DIVISION PROTEIN DEDD-RELATED
14 18 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
145 209 MobiDBLite mobidb-lite consensus disorder prediction
1 1 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
207 282 ProSiteProfiles PS51724 SPOR domain profile.
207 282 InterPro IPR007730 Sporulation-like domain
1 284 Hamap MF_02039 Cell division protein FtsN [ftsN].
1 284 InterPro IPR011930 Cell division protein FtsN
19 284 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GGY9
AlphaFold — — full sequence — Viewing
ColabFold KP13_00576
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
27 0.481
1 0.0
5 0.0
30 0.0