Protein profile

KP13_00583

Periplasmic protein cpxP

Genome: KpKP13

Gene: AHE47058.1 cpxP Structure source: AlphaFold + ColabFold UniProt A0A0H3GK71
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Amino acids 168
Annotations 3
Features 16
PDB binders 0
Druggability 0.573

Overview

Basic information about this protein and its source genome.

Accession
KP13_00583
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47058.1 cpxP
Status
annotated
Amino acids
168
Structure source
AlphaFold + ColabFold
GO
GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0051082 Binding to an unfolded protein.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Periplasmic
ColabFold pLDDT
76.15

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.573
Structure A0A0H3GK71
Pocket Pocket 14
P2Rank 0.014
Structure A0A0H3GK71
Pocket Pocket 1
ColabFold model
FPocket 0.628 · Pocket 2
P2Rank 0.042 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 77 / 4744 genomes with a hit
Normalized 0.016

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
  • GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
  • GO:0051082 Binding to an unfolded protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
5 16 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 22 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
38 152 Gene3D G3DSA:1.20.120.1490 -
2 155 PANTHER PTHR38102 PERIPLASMIC CHAPERONE SPY
50 70 Coils Coil Coil
23 168 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 22 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
41 137 Pfam PF07813 LTXXQ motif family protein
41 137 InterPro IPR012899 LTXXQ motif family protein
49 141 CDD cd09916 CpxP_like
49 141 InterPro IPR012899 LTXXQ motif family protein
2 147 PIRSF PIRSF034445 CpxP_Spy
2 147 InterPro IPR012899 LTXXQ motif family protein
1 22 Phobius SIGNAL_PEPTIDE Signal peptide region
17 22 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 4 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GK71
AlphaFold — — full sequence — Viewing
ColabFold KP13_00583
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
14 0.573
7 0.008
15 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.39 0.014
2 0.95 0.004