Protein profile

KP13_00586

hypothetical protein

Genome: KpKP13

Gene: AHE47061.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GGX9
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Amino acids 224
Annotations 3
Features 10
PDB binders 0
Druggability 0.71

Overview

Basic information about this protein and its source genome.

Accession
KP13_00586
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47061.1
Status
annotated
Amino acids
224
Structure source
AlphaFold + ColabFold
GO
GO:0030151 Binding to a molybdenum ion (Mo). GO:0030170 Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
96.07

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.71
Structure A0A0H3GGX9
Pocket Pocket 1
P2Rank 0.942
Structure A0A0H3GGX9
Pocket Pocket 1
ColabFold model
FPocket 0.68 · Pocket 1
P2Rank 0.937 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 101 / 4744 genomes with a hit
Normalized 0.021

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0030151 Binding to a molybdenum ion (Mo).
  • GO:0030170 Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
  • GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
1 224 Gene3D G3DSA:2.40.33.20 -
4 224 PANTHER PTHR30212 UNCHARACTERIZED
2 223 SUPERFAMILY SSF50800 PK beta-barrel domain-like
2 223 InterPro IPR011037 Pyruvate kinase-like, insert domain superfamily
26 163 ProSiteProfiles PS51340 MOSC domain profile.
26 163 InterPro IPR005302 Molybdenum cofactor sulfurase, C-terminal
47 157 Pfam PF03473 MOSC domain
47 157 InterPro IPR005302 Molybdenum cofactor sulfurase, C-terminal
169 210 Pfam PF03475 3-alpha domain
169 210 InterPro IPR005163 YiiM-like, 3-alpha helix domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GGX9
AlphaFold — — full sequence — Viewing
ColabFold KP13_00586
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.71
18 0.384

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 15.03 0.742
2 6.48 0.328