Protein profile

KP13_00589

HTH-type transcriptional activator rhaR

Genome: KpKP13

Gene: AHE47064.1 rhaR Structure source: AlphaFold + ColabFold UniProt A0A0H3GGA9
Export view
Amino acids 281
Annotations 6
Features 26
PDB binders 0
Druggability 0.689

Overview

Basic information about this protein and its source genome.

Accession
KP13_00589
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47064.1 rhaR
Status
annotated
Amino acids
281
Structure source
AlphaFold + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0045893 Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0019299 OBSOLETE. The chemical reactions and pathways involving rhamnose, the hexose 6-deoxy-L-mannose. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
93.39

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.689
Structure A0A0H3GGA9
Pocket Pocket 2
P2Rank 0.594
Structure A0A0H3GGA9
Pocket Pocket 1
ColabFold model
FPocket 0.388 · Pocket 3
P2Rank 0.516 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 73 / 4744 genomes with a hit
Normalized 0.015

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0045893 Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
  • GO:0019299 OBSOLETE. The chemical reactions and pathways involving rhamnose, the hexose 6-deoxy-L-mannose. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids.

Sequence Features

Domain/signature hits from InterPro and related databases.

26 records
Show feature table
Start End DB Term Name
6 95 Gene3D G3DSA:2.60.120.10 Jelly Rolls
6 95 InterPro IPR014710 RmlC-like jelly roll fold
24 279 PANTHER PTHR43280 ARAC-FAMILY TRANSCRIPTIONAL REGULATOR
243 258 PRINTS PR00032 AraC bacterial regulatory protein HTH signature
243 258 InterPro IPR020449 Transcription regulator HTH, AraC- type
258 274 PRINTS PR00032 AraC bacterial regulatory protein HTH signature
258 274 InterPro IPR020449 Transcription regulator HTH, AraC- type
17 162 CDD cd06977 cupin_RhaR_RhaS-like_N
17 162 InterPro IPR047220 HTH-type transcriptional activator RhaR/RhaS, N-terminal domain
228 270 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature.
228 270 InterPro IPR018062 HTH domain AraC-type, conserved site
26 161 SUPERFAMILY SSF51215 Regulatory protein AraC
26 161 InterPro IPR037923 Transcription regulator HTH-like
176 280 Gene3D G3DSA:1.10.10.60 -
227 277 SUPERFAMILY SSF46689 Homeodomain-like
227 277 InterPro IPR009057 Homeobox-like domain superfamily
191 274 SMART SM00342 aracneu4
191 274 InterPro IPR018060 DNA binding HTH domain, AraC-type
1 281 Hamap MF_01533 HTH-type transcriptional activator RhaR [rhaR].
1 281 InterPro IPR023699 Transcription activator HTH, RhaR
198 276 Pfam PF12833 Helix-turn-helix domain
198 276 InterPro IPR018060 DNA binding HTH domain, AraC-type
22 145 Pfam PF02311 AraC-like ligand binding domain
22 145 InterPro IPR003313 AraC-type arabinose-binding/dimerisation domain
178 276 ProSiteProfiles PS01124 Bacterial regulatory proteins, araC family DNA-binding domain profile.
178 276 InterPro IPR018060 DNA binding HTH domain, AraC-type

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GGA9
AlphaFold — — full sequence — Viewing
ColabFold KP13_00589
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.689

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 8.66 0.463
2 8.15 0.434
3 1.66 0.028
4 1.26 0.013