Protein profile

KP13_00600

Raffinose permease

Genome: KpKP13

Gene: AHE47075.1 rafB Structure source: AlphaFold + ColabFold UniProt A0A0H3GPM5
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Amino acids 435
Annotations 4
Features 71
PDB binders 0
Druggability 0.709

Overview

Basic information about this protein and its source genome.

Accession
KP13_00600
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47075.1 rafB
Status
annotated
Amino acids
435
Structure source
AlphaFold + ColabFold
GO
GO:0008643 The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005351 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: carbohydrate(out) + H+(out) = carbohydrate(in) + H+(in). GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
58.734
DEG E-value
3.3e-170
Localization
CytoplasmicMembrane
ColabFold pLDDT
83.68

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.709
Structure A0A0H3GPM5
Pocket Pocket 1
P2Rank 0.956
Structure A0A0H3GPM5
Pocket Pocket 1
ColabFold model
FPocket 0.311 · Pocket 26
P2Rank 0.935 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 57 / 4744 genomes with a hit
Normalized 0.012

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0008643 The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0005351 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: carbohydrate(out) + H+(out) = carbohydrate(in) + H+(in).
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

71 records
Show feature table
Start End DB Term Name
299 313 ProSitePatterns PS00897 LacY family proton/sugar symporters signature 2.
299 313 InterPro IPR018457 LacY/RafB permease family, conserved site
278 298 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
122 144 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
28 419 CDD cd06172 MFS_LacY
421 435 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
367 389 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
23 424 SUPERFAMILY SSF103473 MFS general substrate transporter
23 424 InterPro IPR036259 MFS transporter superfamily
399 421 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
23 424 Pfam PF01306 LacY proton/sugar symporter
23 424 InterPro IPR000576 LacY/RafB permease family
144 163 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
65 85 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
28 53 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
27 423 ProSiteProfiles PS50850 Major facilitator superfamily (MFS) profile.
27 423 InterPro IPR020846 Major facilitator superfamily domain
259 277 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
309 331 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
24 429 PANTHER PTHR23522 BLL5896 PROTEIN
225 435 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
225 435 InterPro IPR036259 MFS transporter superfamily
95 117 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
330 334 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
187 206 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 27 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
357 367 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
23 224 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
23 224 InterPro IPR036259 MFS transporter superfamily
116 120 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
241 258 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
207 240 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
164 181 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
25 419 NCBIfam TIGR00882 oligosaccharide MFS transporter
25 419 InterPro IPR000576 LacY/RafB permease family
54 64 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
299 309 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
97 115 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
83 97 ProSitePatterns PS00896 LacY family proton/sugar symporters signature 1.
83 97 InterPro IPR018457 LacY/RafB permease family, conserved site
164 182 PRINTS PR00174 LacY proton/sugar symporter family signature
164 182 InterPro IPR000576 LacY/RafB permease family
233 261 PRINTS PR00174 LacY proton/sugar symporter family signature
233 261 InterPro IPR000576 LacY/RafB permease family
334 353 PRINTS PR00174 LacY proton/sugar symporter family signature
334 353 InterPro IPR000576 LacY/RafB permease family
303 329 PRINTS PR00174 LacY proton/sugar symporter family signature
303 329 InterPro IPR000576 LacY/RafB permease family
87 116 PRINTS PR00174 LacY proton/sugar symporter family signature
87 116 InterPro IPR000576 LacY/RafB permease family
122 144 PRINTS PR00174 LacY proton/sugar symporter family signature
122 144 InterPro IPR000576 LacY/RafB permease family
365 385 PRINTS PR00174 LacY proton/sugar symporter family signature
365 385 InterPro IPR000576 LacY/RafB permease family
279 300 PRINTS PR00174 LacY proton/sugar symporter family signature
279 300 InterPro IPR000576 LacY/RafB permease family
389 399 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
182 186 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
310 329 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
27 49 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
164 183 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
341 360 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
280 302 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
335 356 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
187 206 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
86 96 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
368 388 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
400 420 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
64 86 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
243 265 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
121 143 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GPM5
AlphaFold — — full sequence — Viewing
ColabFold KP13_00600
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.709
5 0.701

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 31.86 0.941
2 1.46 0.02
3 1.21 0.011
4 0.75 0.002