Protein profile

KP13_00612

Protein fdhE

Genome: KpKP13

Gene: AHE47086.1 fdhE Structure source: AlphaFold + ColabFold UniProt A0A0H3GG77
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Amino acids 309
Annotations 4
Features 17
PDB binders 0
Druggability 0.486

Overview

Basic information about this protein and its source genome.

Accession
KP13_00612
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47086.1 fdhE
Status
annotated
Amino acids
309
Structure source
AlphaFold + ColabFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008199 Binding to a ferric iron ion, Fe(III). GO:0051604 Any process leading to the attainment of the full functional capacity of a protein.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
51.603
DEG E-value
9.74e-108
Localization
Cytoplasmic
ColabFold pLDDT
93.3

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.486
Structure A0A0H3GG77
Pocket Pocket 14
P2Rank 0.385
Structure A0A0H3GG77
Pocket Pocket 1
ColabFold model
FPocket 0.39 · Pocket 1
P2Rank 0.287 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 130 / 4744 genomes with a hit
Normalized 0.027

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0008199 Binding to a ferric iron ion, Fe(III).
  • GO:0051604 Any process leading to the attainment of the full functional capacity of a protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
23 308 Gene3D G3DSA:3.90.1670.10 -
23 308 InterPro IPR024064 FdhE-like superfamily
2 305 NCBIfam TIGR01562 formate dehydrogenase accessory protein FdhE
2 305 InterPro IPR006452 Formate dehydrogenase accessory protein
24 306 SUPERFAMILY SSF144020 FdhE-like
24 306 InterPro IPR024064 FdhE-like superfamily
1 309 PIRSF PIRSF018296 Format_dh_formtn_FdhE
1 309 InterPro IPR006452 Formate dehydrogenase accessory protein
51 293 CDD cd16341 FdhE
51 293 InterPro IPR006452 Formate dehydrogenase accessory protein
24 308 FunFam G3DSA:3.90.1670.10:FF:000001 Protein FdhE
1 307 PANTHER PTHR37689 PROTEIN FDHE
1 307 InterPro IPR006452 Formate dehydrogenase accessory protein
21 304 Pfam PF04216 Protein involved in formate dehydrogenase formation
21 304 InterPro IPR006452 Formate dehydrogenase accessory protein
3 306 Hamap MF_00611 Protein FdhE [fdhE].
3 306 InterPro IPR006452 Formate dehydrogenase accessory protein

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GG77
AlphaFold — — full sequence — Viewing
ColabFold KP13_00612
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.215
5 0.148
12 0.013
1 0.005

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 8.47 0.385
2 7.04 0.305
3 3.38 0.096
4 1.45 0.016
5 1.26 0.011